Figure 1
From: Blood borne transit of CJD from brain to gut at early stages of infection
Representative sections of gut, spleen, and brain stained for abnormal PrP at sequential times after ic inoculation. (A – C) No pathologic PrP is observed four days after inoculation. (D – F) Only lymphoid tissues are positive 32 days after inoculation. (G – I) Clinically ill mice show abnormal PrP accumulation in brain as well as in lymphoid tissues 120 days after inoculation. The arrow in H shows a positive cell outside the germinal center that is morphologically consistent with a macrophage or dendritic cell. Methods for inoculation, fixation and detection of PrP detection have been described previously [1].