Figure 7

Stereodiagram of two best docked modified cellotetraose units (CTAP) (marked as Dock1 and Dock2, respectively) on the x-ray crystal structure of gp120 (HXBc2 strain) with the V3 loop attached. The residues on gp120 nearest to the docked CTAPs are shown to indicate possible interaction patterns. The V3 loop (peptide 303–338) is indicated in yellow. Regions corresponding to peptides 113–142, 280–306, 361–392 and 393–417 (Fig. 4) are indicated in orange, green, red and purple, respectively. The coreceptor binding site is indicated in gray. The rest of the gp120 is in cyan. The figure was generated using the Sybyl program [54].