The efficacy of chemical agents in cleaning and disinfection programs

Penna, Thereza Christina Vessoni; Mazzola, Priscila Gava; Silva Martins, Alzira Maria

doi:10.1186/1471-2334-1-16

BMC Infectious Diseases

Table 2 The minimum inhibitory concentrations (MIC) for the chemical agent solutions to reduce bacteria populations over 6-log₁₀.

From: The efficacy of chemical agents in cleaning and disinfection programs

Bacteria	Bacillus		Bacillus subtilis		Acinetobacter		Enterobacter		Escherichia coli		Serratia		Staphylococcus
	stearothermophilus				calcoaceticus		cloacae				marcescens		aureus
MIC	mg/L	%	mg/L	%	mg/L	%	mg/L	%	mg/L	%	mg/L	%	mg/L	%
Agent
QACs	156	0.0156	117	0.0117	9.77	0.0010	78	0.0078	59	0.0059	59	0.0059	59	0.0059
Chlorhexidine	^*	^*	10000	1.0	63	0.0063	71	0.0071	71	0.0071	141	0.0141	71	0.0071
Glutaraldehyde	1875	0.1875	3250	0.325	3250	0.325	3250	0.325	3250	0.325	1375	0.1375	1875	0.1875
Formaldehyde	246	0.0246	235	0.0235	39	0.0039	117	0.0117	156	0.0156	58.5	0.0059	156	0.0156
Alcohol	87500	8.75	87500	8.75	43750	4.375	87500	8.75	65650	6.565	43750	4.375	87500	8.75
EtOH (+ glycerin)	^*	^*	^*	^*	87500	8.75	87500	8.75	87500	8.75	87500	8.75	87500	8.75
EtOH (+I₂ 1%)	87500	8.75	87500	8.75	43750	4.375	87500	8.75	43750	4.375	43750	4.375	43750	4.375
I₂ 1% in EtOH	1250	0.125	1250	0.125	1250	0.125	1250	0.125	625	0.0625	625	0.0625	625	0.0625
EtOH (+ I₂ 10%)	-	-	43750	4.375	-	-	43750	4.375	-	-	-	-	21870	2.187
I₂ 10% in EtOH	-	-	6250	0.625	-	-	6250	0.625	-	-	-	-	3125	0.313
Pvp-I₂-topic	12500	1.25	50000	5.0	12500	1.25	6250	0.625	12500	1.25	6250	0.625	6250	0.625
Pvp-I₂ – soap	6250	0.625	50000	5.0	6250	0.625	6250	0.625	6250	0.625	6250	0.625	6250	0.625
Pvp-I₂ – alcoholic	12500	1.25	25000	2.5	12500	1.25	3125	0.3125	1560	0.156	3125	0.3125	3125	0.3125
CRAs 1% pH > 9	4491	0.4491	4491	0.4491	867	0.0867	420	0.0420	1129	0.1129	474	0.0474	945	0.0945
CRAs 0.1%pH 7	621	0.0621	621	0.0621	150	0.015	150	0.015	150	0.015	150	0.015	150	0.015
NaDCC	5990	0.599	5990	0.599	1123	0.1123	374	0.0374	1123	0.1123	187	0.0187	749	0.0749
H₂O₂	1875	0.1875	1875	0.1875	469	0.0469	1250	0.125	2505	0.250	625	0.0625	938	0.0938
Peracetic acid	4620	0.4620	18500	1.85	9250	0.925	9250	0.925	2310	0.231	9250	0.925	4620	0.462

Legend: QACs – Quaternarium Ammonium Compounds; H₂O₂ – Hydrogen peroxide Alcohol – Ethanol (EtOH) or Isopropanol; EtOH + I₂ (iodine); Pvp-I₂ – polyvinylpyrolidone-iodine CRAs – Chlorine releasing agents (CRAs) – Sodium hypochlorite (NaOCl); NaDCC – Sodium dichloro-isocyanurate (^* no efficacy)

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ISSN: 1471-2334

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