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  1. Research article

    Vitamin D and activated vitamin D in tuberculosis in equatorial Malaysia: a prospective clinical study

    Vitamin D deficiency (low plasma 25-hydroxyvitamin D [25D] concentration) is often reported in tuberculosis. Adjunctive vitamin D has been tested for its potential to improve treatment outcomes, but has proven...

    Anna P. Ralph, Muhammad Redzwan S. Rashid Ali, Timothy William, Kim Piera, Uma Parameswaran, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo and Nicholas M. Anstey

    BMC Infectious Diseases 2017 17:312

    Published on: 27 April 2017

  2. Research article

    Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

    Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI...

    Katherine Plewes, Hugh W.F. Kingston, Aniruddha Ghose, Richard J. Maude, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Mahtab Uddin Hasan, Md. Shafiul Haider, Shamsul Alam, Kim A. Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin W. Yeo, Md. Abul Faiz, Sue J Lee…

    BMC Infectious Diseases 2017 17:313

    Published on: 27 April 2017

  3. Research article

    Direct and indirect effects of influenza vaccination

    After vaccination, vaccinees acquire some protection against infection and/or disease. Vaccination, therefore, reduces the number of infections in the population. Due to this herd protection, not everybody nee...

    Martin Eichner, Markus Schwehm, Linda Eichner and Laetitia Gerlier

    BMC Infectious Diseases 2017 17:308

    Published on: 26 April 2017

  4. Case report

    Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy – a case report

    Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. ...

    Nguyen Thi Cam Huong, Ahmed M. A. Altibi, Nguyen My Hoa, Le Anh Tuan, Samar Salman, Sara Morsy, Nguyen Thi Bich Lien, Nguyen Thanh Truong, Nguyen Thi Hoang Mai, Pham Thi Le Hoa, Nguyen Ba Thang and Van The Trung

    BMC Infectious Diseases 2017 17:311

    Published on: 26 April 2017

  5. Research article

    Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus

    Venezuelan equine encephalitis virus (VEEV) is an alphavirus in the family Togaviridae. VEEV causes a bi-phasic illness in mice where primary replication in lymphoid organs is followed by entry into the central n...

    Paridhi Gupta, Anuj Sharma, Jing Han, Amy Yang, Manish Bhomia, Barbara Knollmann-Ritschel, Raj K Puri and Radha K Maheshwari

    BMC Infectious Diseases 2017 17:309

    Published on: 26 April 2017

  6. Research article

    Novel predictors of neurosyphilis among HIV-negative syphilis patients with neurological symptoms: an observational study

    Known predictors of neurosyphilis were mainly drawn from human immunodeficiency virus (HIV)-infected syphilis patients, which may not be applicable to HIV-negative populations as they have different characteri...

    Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu and Tian-Ci Yang

    BMC Infectious Diseases 2017 17:310

    Published on: 26 April 2017

  7. Case report

    Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?

    Due to its chronic subclinical course and large spectrum of manifestations, leprosy often represents a diagnostic challenge. Even with proper anti-mycobacteria treatment, leprosy follow up remains challenging:...

    Ana Paula Vieira, Maria Angela Bianconcini Trindade, Flávio Jota de Paula, Neusa Yurico Sakai-Valente, Alberto José da Silva Duarte, Francine Brambate Carvalhinho Lemos and Gil Benard

    BMC Infectious Diseases 2017 17:305

    Published on: 24 April 2017

  8. Case report

    Lessons learned by surveillance during the tail-end of the Ebola outbreak in Guinea, June-October 2015: a case series

    By the end of the 2013–2016 West African Ebola Virus Disease (EVD) outbreaks, a total of 3814 cases (probable and confirmed) and 2544 deaths were reported in Guinea. Clearly, surveillance activities aiming at ...

    Mory Keïta, Fatoumata Conté, Boubacar Diallo, Dieudonné Lufwa, Jacques Katomba, René Snacken, Raymond Pallawo, Aminata Tolno, Amadou Bailo Diallo, Mamadou Harouna Djingarey and Lorenzo Subissi

    BMC Infectious Diseases 2017 17:304

    Published on: 24 April 2017

  9. Research article

    Early detection of multidrug- and pre-extensively drug-resistant tuberculosis from smear-positive sputum by direct sequencing

    Emergence of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) is a major hurdle for TB control programs especially in developing countries like China. Resistance to fluoroquinolones is high am...

    Jun Chen, Peng Peng, Yixiang Du, Yi Ren, Lifeng Chen, Youyi Rao and Weihua Wang

    BMC Infectious Diseases 2017 17:300

    Published on: 24 April 2017

  10. Research article

    Viral aetiologies of acute encephalitis in a hospital-based South Asian population

    The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian ...

    Janarthani Lohitharajah, Neelika Malavige, Carukshi Arambepola, Jithangi Wanigasinghe, Ranjanie Gamage, Padma Gunaratne, Pyara Ratnayake and Thashi Chang

    BMC Infectious Diseases 2017 17:303

    Published on: 24 April 2017

  11. Case report

    Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status

    Following its recent certification as malaria-free, imported infections now pose the greatest threat for maintaining this status in Sri Lanka. Imported infections may also introduce species that are uncommon o...

    Sharmini Gunawardena, Rachel F. Daniels, Thishan C. Yahathugoda, Mirani V. Weerasooriya, Katelyn Durfee, Sarah K. Volkman, Dyann F. Wirth and Nadira D. Karunaweera

    BMC Infectious Diseases 2017 17:307

    Published on: 24 April 2017

  12. Research article

    Digital CXR with computer aided diagnosis versus symptom screen to define presumptive tuberculosis among household contacts and impact on tuberculosis diagnosis

    Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However,...

    Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya and Helen Ayles

    BMC Infectious Diseases 2017 17:301

    Published on: 24 April 2017

  13. Research article

    Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis

    African pouched rats sniffing sputum samples provided by local clinics have significantly increased tuberculosis case findings in Tanzania and Mozambique. The objective of this study was to determine the repro...

    Haylee Ellis, Christiaan Mulder, Emilio Valverde, Alan Poling and Timothy Edwards

    BMC Infectious Diseases 2017 17:298

    Published on: 24 April 2017

  14. Research article

    Evaluation of the enhanced meningitis surveillance system, Yendi municipality, northern Ghana, 2010–2015

    Meningitis is the inflammation of the meninges of the brain and or spinal cord. Global mortality rates vary from 2% to 30%. Epidemic meningitis remains a public health concern along the meningitis belt of Afri...

    Basil Benduri Kaburi, Chrysantus Kubio, Ernest Kenu, Kofi Mensah Nyarko, Jacob Yakubu Mahama, Samuel Oko Sackey and Edwin Andrew Afari

    BMC Infectious Diseases 2017 17:306

    Published on: 24 April 2017

  15. Research article

    Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

    A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis...

    Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte…

    BMC Infectious Diseases 2017 17:302

    Published on: 24 April 2017

  16. Research article

    Predictors of delayed culture conversion among Ugandan patients

    Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. T...

    Daniel Atwine, Patrick Orikiriza, Ivan Taremwa, Arnold Ayebare, Suzan Logoose, Juliet Mwanga-Amumpaire, Amina Jindani and Maryline Bonnet

    BMC Infectious Diseases 2017 17:299

    Published on: 24 April 2017

  17. Research article

    Infectious agents is a risk factor for myxomatous mitral valve degeneration: A case control study

    The etiology of myxomatous mitral valve degeneration (MVD) is not fully understood and may depend on time or environmental factors for which the interaction of infectious agents has not been documented. The pu...

    Marcos Gradim Tiveron, Pablo Maria Alberto Pomerantzeff, Maria de Lourdes Higuchi, Marcia Martins Reis, Jaqueline de Jesus Pereira, Joyce Tieko Kawakami, Renata Nishiyama Ikegami, Carlos Manuel de Almeida Brandao and Fabio Biscegli Jatene

    BMC Infectious Diseases 2017 17:297

    Published on: 21 April 2017

  18. Case report

    Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation

    Chromomycosis is a rare mycotic infection encountered in tropical and subtropical regions. The disease presents as a slowly-evolving nodule that can become infected with bacteria. Here, we describe a unique as...

    J. Tourret, N. Benabdellah, S. Drouin, F. Charlotte, J. Rottembourg, N. Arzouk, A. Fekkar and B. Barrou

    BMC Infectious Diseases 2017 17:288

    Published on: 20 April 2017

  19. Research article

    Determinants of delayed care seeking for TB suggestive symptoms in Seru district, Oromiya region, Ethiopia: a community based unmatched case-control study

    Early tuberculosis (TB) case finding and adequate chemotherapy are essential for interrupting disease transmission and preventing complications due to delayed care seeking. This study was undertaken in order t...

    Robel Yirgu, Firaol Lemessa, Selamawit Hirpa, Abraham Alemayehu and Eveline Klinkenberg

    BMC Infectious Diseases 2017 17:292

    Published on: 20 April 2017

  20. Research article

    Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

    Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary...

    Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John and Robert N Davidson

    BMC Infectious Diseases 2017 17:295

    Published on: 20 April 2017

  21. Research article

    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

    Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonize...

    Elly O. Munde, Winnie A. Okeyo, Evans Raballah, Samuel B. Anyona, Tom Were, John M. Ong’echa, Douglas J. Perkins and Collins Ouma

    BMC Infectious Diseases 2017 17:289

    Published on: 20 April 2017

  22. Research article

    Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease

    Cardiovascular disease (CVD) is an important cause of mortality among HIV-infected patients, however little is known about the burden of CVD among this population in Asia. We sought to quantify prevalence of C...

    Fuping Guo, Evelyn Hsieh, Wei Lv, Yang Han, Jing Xie, Yanling Li, Xiaojing Song and Taisheng Li

    BMC Infectious Diseases 2017 17:287

    Published on: 20 April 2017

  23. Research article

    Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

    Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic suscepti...

    Elly O. Munde, Evans Raballah, Winnie A. Okeyo, John M. Ong’echa, Douglas J. Perkins and Collins Ouma

    BMC Infectious Diseases 2017 17:291

    Published on: 20 April 2017

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