Viral diseases

Section edited by Jodie McVernon and Julian Tang

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of viral diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology. HIV, HIV-associated infections and sexually transmitted diseases are considered in separate sections.

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  1. Study protocol

    Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods

    This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clini...

    Mark G. Thompson, Danielle R. Hunt, Ali K. Arbaji, Artan Simaku, Veronica L. Tallo, Holly M. Biggs, Carolyn Kulb, Aubree Gordon, Ilham Abu Khader, Silvia Bino, Marilla G. Lucero, Eduardo Azziz-Baumgartner, Pat Shifflett, Felix Sanchez, Basima I. Marar, Ilirjana Bakalli…

    BMC Infectious Diseases 2017 17:222

    Published on: 22 March 2017

  2. Research article

    Cytomegalovirus, Epstein-Barr virus and varicella zoster virus infection in the first two years of life: a cohort study in Bradford, UK

    Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact...

    Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad and John Wright

    BMC Infectious Diseases 2017 17:220

    Published on: 21 March 2017

  3. Research article

    Seasonal patterns of dengue fever and associated climate factors in 4 provinces in Vietnam from 1994 to 2013

    In Vietnam, dengue fever (DF) is still a leading cause of hospitalization. The main objective of this study was to evaluate the seasonality and association with climate factors (temperature and precipitation) ...

    Hu Suk Lee, Hung Nguyen-Viet, Vu Sinh Nam, Mihye Lee, Sungho Won, Phuc Pham Duc and Delia Grace

    BMC Infectious Diseases 2017 17:218

    Published on: 20 March 2017

  4. Research article

    Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo

    Herpes simplex virus (HSV) is a common human pathogen that causes a variety of diseases, including oral-labial, genital lesions and life-threatening encephalitis. The antiviral nucleoside analogues such as acy...

    Jue Hou, Zili Zhang, Qiang Huang, Jun Yan, Xiaohu Zhang, Xiaoliang Yu, Guihua Tan, Chunfu Zheng, Feng Xu and Sudan He

    BMC Infectious Diseases 2017 17:217

    Published on: 20 March 2017

  5. Research article

    Imported arboviral infections in Italy, July 2014-October 2015: a National Reference Laboratory report

    Imported cases of infections due to Dengue (DENV) and Chikungunya (CHIKV) viruses and, more recently, Zika virus (ZIKV) are commonly reported among travelers returning from endemic regions. In areas where pote...

    Claudia Fortuna, Maria Elena Remoli, Caterina Rizzo, Eleonora Benedetti, Cristiano Fiorentini, Antonino Bella, Claudio Argentini, Francesca Farchi, Concetta Castilletti, Maria Rosaria Capobianchi, Lorenzo Zammarchi, Alessandro Bartoloni, Nadia Zanchetta, Maria Rita Gismondo, Luca Ceccherini Nelli, Giustina Vitale…

    BMC Infectious Diseases 2017 17:216

    Published on: 16 March 2017

  6. Review

    Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific

    Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vu...

    Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M. F. Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S. Poblete…

    BMC Infectious Diseases 2017 17:213

    Published on: 15 March 2017

  7. Research article

    Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases

    Dengue is an acute febrile illness considered the major arboviral disease in terms of morbidity, mortality, economic impact and dissemination worldwide. Brazil accounts for the highest notification rate, with ...

    Sibelle Nogueira Buonora, Flavia Barreto dos Santos, Regina Paiva Daumas, Sonia Regina Lambert Passos, Manoela Heringer da Silva, Monique Rocha de Lima and Rita Maria Ribeiro Nogueira

    BMC Infectious Diseases 2017 17:204

    Published on: 11 March 2017

  8. Technical advance

    ICARES: a real-time automated detection tool for clusters of infectious diseases in the Netherlands

    Clusters of infectious diseases are frequently detected late. Real-time, detailed information about an evolving cluster and possible associated conditions is essential for local policy makers, travelers planni...

    Geert H. Groeneveld, Anton Dalhuijsen, Chakib Kara-Zaïtri, Bob Hamilton, Margot W. de Waal, Jaap T. van Dissel and Jim E. van Steenbergen

    BMC Infectious Diseases 2017 17:201

    Published on: 9 March 2017

  9. Research article

    Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response

    Human adenovirus 7 (HAdV-7) was responsible for a significant number of fatalities during the 2011 community outbreak in Taiwan. The mechanisms underlying the pathogenesis of severe adenovirus infections in no...

    Ching-Fen Shen, Shih-Min Wang, Tzong-Shiann Ho and Ching-Chuan Liu

    BMC Infectious Diseases 2017 17:196

    Published on: 7 March 2017

  10. Research article

    A meta-analysis of stroke risk following herpes zoster infection

    The incidence of herpes zoster (HZ) is increasing and poses a significant health concern to aging populations. Several studies suggest an increased risk of stroke following zoster infection, but the results ar...

    Fawziah Marra, Jeremy Ruckenstein and Kathryn Richardson

    BMC Infectious Diseases 2017 17:198

    Published on: 7 March 2017

  11. Research article

    Clinical manifestations of severe enterovirus 71 infection and early assessment in a Southern China population

    Enterovirus 71 (EV-A71) shows a potential of rapid death, but the natural history of the infection is poorly known. This study aimed to examine the natural history of EV-A71 infection.

    Si-da Yang, Pei-qing Li, Yi-min Li, Wei Li, Wen-ying Lai, Cui-ping Zhu, Jian-ping Tao, Li Deng, Hong-sheng Liu, Wen-cheng Ma, Jia-ming Lu, Yan Hong, Yu-ting Liang, Jun Shen, Dan-dan Hu, Yuan-yuan Gao…

    BMC Infectious Diseases 2017 17:153

    Published on: 17 February 2017

  12. Research article

    Effective inhibition of MERS-CoV infection by resveratrol

    Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines can...

    Shih-Chao Lin, Chi-Tang Ho, Wen-Ho Chuo, Shiming Li, Tony T. Wang and Chi-Chen Lin

    BMC Infectious Diseases 2017 17:144

    Published on: 13 February 2017

  13. Research article

    A population-based study of chronic hepatitis C in immigrants and non-immigrants in Quebec, Canada

    Immigrants originating from intermediate and high HCV prevalence countries may be at increased risk of exposure to hepatitis C infection (HCV) in their countries of origin, however they are not routinely scree...

    Christina Greenaway, Laurent Azoulay, Robert Allard, Joseph Cox, Viet Anh Tran, Claire Nour Abou Chakra, Russ Steele and Marina Klein

    BMC Infectious Diseases 2017 17:140

    Published on: 13 February 2017

  14. Research article

    Viral aetiology of bronchiolitis in hospitalised children in Qatar

    Bronchiolitis is considered one of the earliest and most common causes of hospitalisation in young children. Development of molecular technologies allowed a better understanding of bronchiolitis aetiology. Res...

    Ibrahim Janahi, Anas Abdulkayoum, Fawziya Almeshwesh, Mohamed Alkuwari, Ahmed Al hammadi and Marwah Alameri

    BMC Infectious Diseases 2017 17:139

    Published on: 13 February 2017

  15. Research article

    Study on age-dependent pre-existing 2009 pandemic influenza virus T and B cell responses from Chinese population

    The outbreak of the 2009 H1N1 influenza pandemic (H1N1pdm) affected thousands of people in Mexico and the United States, and spread rapidly throughout the world from April 2009 to July 2010. To explore the age...

    Jin Lv, Zhen-Yong Ren, Ying-Ying Zhang, Yun-E Liu, Jun Gao, Kun Yao, Dan Feng, Zhen-Yuan Li, Xin Feng, Yun-Xi Liu and Na Jia

    BMC Infectious Diseases 2017 17:136

    Published on: 10 February 2017

  16. Correspondence

    Beyond Ebola treatment units: severe infection temporary treatment units as an essential element of Ebola case management during an outbreak

    In the course of the Ebola outbreak in West Africa that was witnessed since early 2014, the response mechanisms showed deficits in terms of timeliness, volume and adequacy. The authors were deployed in the Ebo...

    Christian Janke, Katrin Moira Heim, Florian Steiner, Moses Massaquoi, Miatta Zenabu Gbanya, Claudia Frey and Guenter Froeschl

    BMC Infectious Diseases 2017 17:124

    Published on: 6 February 2017

  17. Study protocol

    Molecular point-of-care testing for respiratory viruses versus routine clinical care in adults with acute respiratory illness presenting to secondary care: a pragmatic randomised controlled trial protocol (ResPOC)

    Respiratory viruses are associated with a huge socio-economic burden and are responsible for a large proportion of acute respiratory illness in hospitalised adults. Laboratory PCR is accurate but takes at leas...

    Nathan J. Brendish, Ahalya K. Malachira and Tristan W. Clark

    BMC Infectious Diseases 2017 17:128

    Published on: 6 February 2017

  18. Research article

    Using a community based survey of healthcare seeking behavior to estimate the actual magnitude of influenza among adults in Beijing during 2013-2014 season

    Due to a lack of survey of health care seeking behavior for influenza, the actual magnitude of influenza in Beijing of China has not been well described.

    Xiaoli Wang, Shuangsheng Wu, Peng Yang, Hongjun Li, Yanhui Chu, Yaqing Tang, Weiyu Hua, Haiyan Zhang, Chao Li and Quanyi Wang

    BMC Infectious Diseases 2017 17:120

    Published on: 3 February 2017

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