Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss, Eyal Oren & Anna Vassall

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Case report

    Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?

    Due to its chronic subclinical course and large spectrum of manifestations, leprosy often represents a diagnostic challenge. Even with proper anti-mycobacteria treatment, leprosy follow up remains challenging:...

    Ana Paula Vieira, Maria Angela Bianconcini Trindade, Flávio Jota de Paula, Neusa Yurico Sakai-Valente, Alberto José da Silva Duarte, Francine Brambate Carvalhinho Lemos and Gil Benard

    BMC Infectious Diseases 2017 17:305

    Published on: 24 April 2017

  2. Research article

    Early detection of multidrug- and pre-extensively drug-resistant tuberculosis from smear-positive sputum by direct sequencing

    Emergence of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) is a major hurdle for TB control programs especially in developing countries like China. Resistance to fluoroquinolones is high am...

    Jun Chen, Peng Peng, Yixiang Du, Yi Ren, Lifeng Chen, Youyi Rao and Weihua Wang

    BMC Infectious Diseases 2017 17:300

    Published on: 24 April 2017

  3. Research article

    Digital CXR with computer aided diagnosis versus symptom screen to define presumptive tuberculosis among household contacts and impact on tuberculosis diagnosis

    Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However,...

    Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya and Helen Ayles

    BMC Infectious Diseases 2017 17:301

    Published on: 24 April 2017

  4. Research article

    Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis

    African pouched rats sniffing sputum samples provided by local clinics have significantly increased tuberculosis case findings in Tanzania and Mozambique. The objective of this study was to determine the repro...

    Haylee Ellis, Christiaan Mulder, Emilio Valverde, Alan Poling and Timothy Edwards

    BMC Infectious Diseases 2017 17:298

    Published on: 24 April 2017

  5. Research article

    Predictors of delayed culture conversion among Ugandan patients

    Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. T...

    Daniel Atwine, Patrick Orikiriza, Ivan Taremwa, Arnold Ayebare, Suzan Logoose, Juliet Mwanga-Amumpaire, Amina Jindani and Maryline Bonnet

    BMC Infectious Diseases 2017 17:299

    Published on: 24 April 2017

  6. Research article

    Determinants of delayed care seeking for TB suggestive symptoms in Seru district, Oromiya region, Ethiopia: a community based unmatched case-control study

    Early tuberculosis (TB) case finding and adequate chemotherapy are essential for interrupting disease transmission and preventing complications due to delayed care seeking. This study was undertaken in order t...

    Robel Yirgu, Firaol Lemessa, Selamawit Hirpa, Abraham Alemayehu and Eveline Klinkenberg

    BMC Infectious Diseases 2017 17:292

    Published on: 20 April 2017

  7. Research article

    Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

    Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary...

    Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John and Robert N Davidson

    BMC Infectious Diseases 2017 17:295

    Published on: 20 April 2017

  8. Research article

    Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples

    Multi drug resistant tuberculosis (MDR-TB) poses formidable challenges to TB control due to its complex diagnostic and treatment challenges and often associated with a high rate of mortality. Accurate and rapi...

    Abyot Meaza, Abebaw Kebede, Zelalem Yaregal, Zekarias Dagne, Shewki Moga, Bazezew Yenew, Getu Diriba, Helina Molalign, Mengistu Tadesse, Desalegn Adisse, Muluwork Getahun and Kassu Desta

    BMC Infectious Diseases 2017 17:280

    Published on: 17 April 2017

  9. Research article

    TST positivity in household contacts of tuberculosis patients: a case-contact study in Malawi

    Screening household contacts of active tuberculosis (TB) patients is recommended for TB control. Due to resource constraints this rarely occurs in lower income countries. Demographic and clinical features of i...

    Jonas Hector, Suzanne T. Anderson, Gertrude Banda, Mercy Kamdolozi, Laura F. Jefferys, Doris Shani, Natalie J. Garton, Agnes Mwale, Annie Jobe, Geraint R. Davies and Derek J Sloan

    BMC Infectious Diseases 2017 17:259

    Published on: 11 April 2017

  10. Research article

    Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire

    In Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. Zinc and copper are essential Trace element needed to strengthen the ...

    Gnogbo Alexis Bahi, Lydie Boyvin, Souleymane Méité, Gervais Melaine M’Boh, Kadjowely Yeo, Kouassi Raymond N’Guessan, Alain Dit Philippe Bidié and Allico Joseph Djaman

    BMC Infectious Diseases 2017 17:257

    Published on: 11 April 2017

  11. Research article

    Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens for latent tuberculosis infection: a systematic review with network meta-analyses

    We conducted a systematic review and network meta-analysis (NMA) to examine the efficacy and completion rates of treatments for latent tuberculosis infection (LTBI). While a previous review found newer, short-...

    Christopher Pease, Brian Hutton, Fatemeh Yazdi, Dianna Wolfe, Candyce Hamel, Pauline Quach, Becky Skidmore, David Moher and Gonzalo G. Alvarez

    BMC Infectious Diseases 2017 17:265

    Published on: 11 April 2017

  12. Research article

    Development and validation of a prognostic score during tuberculosis treatment

    Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas.

    Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Hadja Koté Fatime-Abaicho, Patrick Thierry Enono-Edende and André Pascal Kengne

    BMC Infectious Diseases 2017 17:251

    Published on: 8 April 2017

  13. Research article

    The prevalence of HIV among adults with pulmonary TB at a population level in Zambia

    Tuberculosis and HIV co-infection is one of the main drivers of poor outcome for both diseases in Zambia. HIV infection has been found to predict TB infection/disease and TB has been reported as a major cause ...

    Pascalina Chanda-Kapata, Nathan Kapata, Eveline Klinkenberg, Martin P. Grobusch and Frank Cobelens

    BMC Infectious Diseases 2017 17:236

    Published on: 29 March 2017

  14. Research article

    Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

    We describe drug-induced liver injury (DILI) secondary to antituberculous treatment (ATT) in a large tuberculosis (TB) centre in London; we identify the proportion who had risk factors for DILI and the timing ...

    Aula Abbara, Sarah Chitty, Jennifer K. Roe, Rohma Ghani, Simon M. Collin, Andrew Ritchie, Onn Min Kon, John Dzvova, Harriet Davidson, Thomas E. Edwards, Charlotte Hateley, Matthew Routledge, Jim Buckley, Robert N. Davidson and Laurence John

    BMC Infectious Diseases 2017 17:231

    Published on: 24 March 2017

  15. Research article

    Multidrug resistant tuberculosis in Ethiopian settings and its association with previous history of anti-tuberculosis treatment: a systematic review and meta-analysis

    Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifamp...

    Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema and Feleke Moges

    BMC Infectious Diseases 2017 17:219

    Published on: 20 March 2017

  16. Research article

    Prevalence and Incidence of Smear-Positive Pulmonary Tuberculosis in the Hetosa District of Arsi Zone, Oromia Regional State of Central Ethiopia

    The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of...

    ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen and Bernt Lindtjørn

    BMC Infectious Diseases 2017 17:214

    Published on: 16 March 2017

  17. Research article

    Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis

    Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening test...

    Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe and Aileen Clarke

    BMC Infectious Diseases 2017 17:200

    Published on: 9 March 2017

  18. Study protocol

    Screening in Maternity to Ascertain Tuberculosis Status (SMATS) study

    Diagnosis of tuberculosis is difficult among pregnant women because the signs and symptoms of the disease, such as fatigue, shortness of breath, sweating, cough, and mild fever are similar to some manifestatio...

    Edward Broughton, Samson Haumba, Marianne Calnan, Sandile Ginindsa, Rosanna Jeffries, Gugu Maphalala, Sikhathele Mazibuko, Munamato Mirara, Surbhi Modi, Pasipamire Munyaradzi, Peter Preko and Batsabile Simelane

    BMC Infectious Diseases 2017 17:191

    Published on: 6 March 2017

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