Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss, Eyal Oren & Anna Vassall

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Research article

    Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK

    We describe drug-induced liver injury (DILI) secondary to antituberculous treatment (ATT) in a large tuberculosis (TB) centre in London; we identify the proportion who had risk factors for DILI and the timing ...

    Aula Abbara, Sarah Chitty, Jennifer K. Roe, Rohma Ghani, Simon M. Collin, Andrew Ritchie, Onn Min Kon, John Dzvova, Harriet Davidson, Thomas E. Edwards, Charlotte Hateley, Matthew Routledge, Jim Buckley, Robert N. Davidson and Laurence John

    BMC Infectious Diseases 2017 17:231

    Published on: 24 March 2017

  2. Research article

    Multidrug resistant tuberculosis in Ethiopian settings and its association with previous history of anti-tuberculosis treatment: a systematic review and meta-analysis

    Efforts to control the global burden of tuberculosis (TB) have been jeopardized by the rapid evolution of multi-drug resistant Mycobacterium tuberculosis (MTB), which is resistant to at least isoniazid and rifamp...

    Setegn Eshetie, Mucheye Gizachew, Mulat Dagnew, Gemechu Kumera, Haile Woldie, Fekadu Ambaw, Belay Tessema and Feleke Moges

    BMC Infectious Diseases 2017 17:219

    Published on: 20 March 2017

  3. Research article

    Prevalence and Incidence of Smear-Positive Pulmonary Tuberculosis in the Hetosa District of Arsi Zone, Oromia Regional State of Central Ethiopia

    The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of...

    ShalloDaba Hamusse, Meaza Demissie, Dejene Teshome, Mohammed Suaudi Hassen and Bernt Lindtjørn

    BMC Infectious Diseases 2017 17:214

    Published on: 16 March 2017

  4. Research article

    Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis

    Timely and accurate identification of people with latent tuberculosis infection (LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold standard for diagnosis of LTBI. Screening test...

    Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Noel McCarthy, Paul Sutcliffe and Aileen Clarke

    BMC Infectious Diseases 2017 17:200

    Published on: 9 March 2017

  5. Study protocol

    Screening in Maternity to Ascertain Tuberculosis Status (SMATS) study

    Diagnosis of tuberculosis is difficult among pregnant women because the signs and symptoms of the disease, such as fatigue, shortness of breath, sweating, cough, and mild fever are similar to some manifestatio...

    Edward Broughton, Samson Haumba, Marianne Calnan, Sandile Ginindsa, Rosanna Jeffries, Gugu Maphalala, Sikhathele Mazibuko, Munamato Mirara, Surbhi Modi, Pasipamire Munyaradzi, Peter Preko and Batsabile Simelane

    BMC Infectious Diseases 2017 17:191

    Published on: 6 March 2017

  6. Research article

    Molecular typing of Mycobacterium tuberculosis complex isolated from pulmonary tuberculosis patients in central Ethiopia

    Identification of the types of strains of Mycobacterium tuberculosis (M. tuberculosis) complex causing tuberculosis (TB) could contribute to TB control program of specific geographic region as well as it could ad...

    Zufan Bedewi, Adane Worku, Yalemtsehay Mekonnen, Getnet Yimer, Girmay Medhin, Gezahegne Mamo, Rembert Pieper and Gobena Ameni

    BMC Infectious Diseases 2017 17:184

    Published on: 1 March 2017

  7. Research article

    High mortality among tuberculosis patients on treatment in Nigeria: a retrospective cohort study

    Tuberculosis (TB) remains a leading cause of death in much of sub-Saharan Africa despite available effective treatment. Prompt initiation of TB treatment and access to antiretroviral therapy (ART) remains vita...

    Aishatu L. Adamu, Muktar A. Gadanya, Isa S. Abubakar, Abubakar M. Jibo, Musa M. Bello, Auwalu U. Gajida, Musa M. Babashani and Ibrahim Abubakar

    BMC Infectious Diseases 2017 17:170

    Published on: 23 February 2017

  8. Research article

    Factors associated with the length of delay with tuberculosis diagnosis and treatment among adult tuberculosis patients attending at public health facilities in Gondar town, Northwest, Ethiopia

    Early diagnosis and prompt treatment is essential for an effective tuberculosis (TB) control program. However, significant proportion of cases remains undiagnosed and untreated. Delay in diagnosis and treatmen...

    Selamsew Bogale, Ermias Diro, Atsede Mazengia Shiferaw and Melaku Kindie Yenit

    BMC Infectious Diseases 2017 17:145

    Published on: 14 February 2017

  9. Research article

    Treatment completion for latent tuberculosis infection: a retrospective cohort study comparing 9 months of isoniazid, 4 months of rifampin and 3 months of isoniazid and rifapentine

    The U.S. Centers for Disease Control and Prevention (CDC) recommended a new regimen for treatment of latent tuberculosis (three months of weekly isoniazid and rifapentine) in late 2011. While completion rates ...

    Adelaide H. McClintock, McKenna Eastment, Christy M. McKinney, Caroline L. Pitney, Masahiro Narita, David R. Park, Shireesha Dhanireddy and Alexandra Molnar

    BMC Infectious Diseases 2017 17:146

    Published on: 14 February 2017

  10. Research article

    Association of high serum vitamin D concentrations with active pulmonary TB in an HIV co-endemic setting, Harare, Zimbabwe

    There is paucity data on the association of vitamin D deficiency (VDD) and active tuberculosis (TB) in southern Africa where the human immunodeficiency virus (HIV) is co-endemic. We examined the association of...

    Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Duri, Kudzie Mateveke-Dangaiso, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma and Witmore Bayayi Mujaji

    BMC Infectious Diseases 2017 17:142

    Published on: 13 February 2017

  11. Research article

    Risk factors for poor multidrug-resistant tuberculosis treatment outcomes in Kyiv Oblast, Ukraine

    Ukraine is among ten countries with the highest burden of multidrug- resistant TB (MDR-TB) worldwide. Treatment success rates for MDR-TB in Ukraine remain below global success rates as reported by the World He...

    Omowunmi Aibana, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P. Flanigan, Vasyl Petrenko and Megan B. Murray

    BMC Infectious Diseases 2017 17:129

    Published on: 7 February 2017

  12. Research article

    Early interventions for diabetes related tuberculosis associate with hastened sputum microbiological clearance in Virginia, USA

    Diabetes complicates tuberculosis (TB) treatment including a prolonged time of sputum culture conversion to negative growth. Since 2013 in Virginia, interventions early in the treatment course have used therap...

    Yosra Alkabab, Suzanne Keller, Denise Dodge, Eric Houpt, Deborah Staley and Scott Heysell

    BMC Infectious Diseases 2017 17:125

    Published on: 6 February 2017

  13. Research article

    Why being an expert – despite xpert –remains crucial for children in high TB burden settings

    As access to Xpert expands in high TB-burden settings, its performance against clinically diagnosed TB as a reference standard provides important insight as the majority of childhood TB is bacteriologically un...

    Jason M. Bacha, Katherine Ngo, Petra Clowes, Heather R. Draper, Elias N. Ntinginya, Andrew DiNardo, Chacha Mangu, Issa Sabi, Bariki Mtafya and Anna M. Mandalakas

    BMC Infectious Diseases 2017 17:123

    Published on: 6 February 2017

  14. Research article

    Treatment outcomes of fixed-dose combination versus separate tablet regimens in pulmonary tuberculosis patients with or without diabetes in Qatar

    Tuberculosis is considered the second most common cause of death due to infectious agent. The currently preferred regimen for treatment of pulmonary tuberculosis (PTB) is isoniazid, rifampin, pyrazinamide, and...

    Mohammad H. Al-Shaer, Hanine Mansour, Hazem Elewa, Pascale Salameh and Fatima Iqbal

    BMC Infectious Diseases 2017 17:118

    Published on: 2 February 2017

  15. Research article

    Smear positive pulmonary tuberculosis and associated risk factors among tuberculosis suspects attending spiritual holy water sites in Northwest Ethiopia

    Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. In Ethiopia, tuberculosis patients have different pattern of health care seeking behavior. They usually adopt other approaches like...

    Dejene Derseh, Feleke Moges and Belay Tessema

    BMC Infectious Diseases 2017 17:100

    Published on: 26 January 2017

  16. Research article

    The effect of the Xpert MTB/RIF test on the time to MDR-TB treatment initiation in a rural setting: a cohort study in South Africa’s Eastern Cape Province

    There are significant delays in initiation of multidrug-resistant tuberculosis (MDR –TB) treatment. The Xpert MTB/RIF test has been shown to reduce the time to diagnosis and treatment of MDR-TB predominantly i...

    Joshua Iruedo, Don O’Mahony, Sikhumbuzo Mabunda, Graham Wright and Busisiwe Cawe

    BMC Infectious Diseases 2017 17:91

    Published on: 21 January 2017

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