Tuberculosis and other mycobacterial diseases

Section edited by Edward Graviss, Eyal Oren & Anna Vassall

This section aims to publish studies looking at all aspects of of the prevention, diagnosis and management of tuberculosis and other mycobacterial diseases in humans, including HIV-associated tuberculosis, as well as related molecular genetics, pathophysiology, and epidemiology.

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  1. Research article

    Genetic diversity of Mycobacterium tuberculosis isolates from Tochigi prefecture, a local region of Japan

    Foreign-born patients with tuberculosis (TB) may introduce globally disseminated isolates of Mycobacterium tuberculosis into large cities in Japan. The risk of dissemination of these isolates into local regions, ...

    Fuminori Mizukoshi, Tohru Miyoshi-Akiyama, Hiroki Iwai, Takako Suzuki, Reiko Kiritani, Teruo Kirikae and Keiji Funatogawa

    BMC Infectious Diseases 2017 17:365

    Published on: 25 May 2017

  2. Research article

    Comparison of antibody responses against Mycobacterium tuberculosis antigen Rv0679c in tuberculosis patients from the endemic and non-endemic regions of the Beijing genotype: a case control study

    Strains of the Beijing genotype of Mycobacterium tuberculosis (MTB) are reportedly associated with the virulence of tuberculosis (TB) infection, unfavorable outcomes of anti-TB treatment, and the global TB pandem...

    Jingge Zhao, Takashi Matsuba, Xiaoyan Zhang, Susan Leano, Chie Nakajima, Haorile Chagan-Yasutan, Elizabeth Freda Telan, Yasuhiko Suzuki and Toshio Hattori

    BMC Infectious Diseases 2017 17:344

    Published on: 15 May 2017

  3. Research article

    Early morning urine collection to improve urinary lateral flow LAM assay sensitivity in hospitalised patients with HIV-TB co-infection

    Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We therefore examined the incremental diagnostic sensit...

    Phindile Gina, Philippa J. Randall, Tapuwa E. Muchinga, Anil Pooran, Richard Meldau, Jonny G. Peter and Keertan Dheda

    BMC Infectious Diseases 2017 17:339

    Published on: 12 May 2017

  4. Research article

    Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory

    The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection aga...

    Lander Bosch, Barbara Bosch, Kris De Boeck, Tim Nawrot, Isabelle Meyts, Dominique Vanneste, Cleonice Alexandre Le Bourlegat, Julio Croda and Luiz Vicente Ribeiro Ferreira da Silva Filho

    BMC Infectious Diseases 2017 17:340

    Published on: 12 May 2017

  5. Research article

    Comparing tuberculosis management under public and private healthcare providers: Victoria, Australia, 20022015

    Private healthcare providers are important to tuberculosis (TB) management globally, although internationally there are reports of suboptimal management and disparities in treatment commencement in the private...

    Katie D. Dale, Ee Laine Tay, James M. Trauer, Peter G. Trevan and Justin T. Denholm

    BMC Infectious Diseases 2017 17:324

    Published on: 3 May 2017

  6. Research article

    Modeling the patient and health system impacts of alternative xpert® MTB/RIF algorithms for the diagnosis of pulmonary tuberculosis in Addis Ababa, Ethiopia

    To reduce global tuberculosis (TB) burden, the active disease must be diagnosed quickly and accurately and patients should be treated and cured. In Ethiopia, TB diagnosis mainly relies on spot-morning-spot (SM...

    Abraham Tesfaye, Daniel Fiseha, Dawit Assefa, Eveline Klinkenberg, Silvia Balanco and Ivor Langley

    BMC Infectious Diseases 2017 17:318

    Published on: 2 May 2017

  7. Research article

    Vitamin D and activated vitamin D in tuberculosis in equatorial Malaysia: a prospective clinical study

    Vitamin D deficiency (low plasma 25-hydroxyvitamin D [25D] concentration) is often reported in tuberculosis. Adjunctive vitamin D has been tested for its potential to improve treatment outcomes, but has proven...

    Anna P. Ralph, Muhammad Redzwan S. Rashid Ali, Timothy William, Kim Piera, Uma Parameswaran, Elspeth Bird, Christopher S. Wilkes, Wai Khew Lee, Tsin Wen Yeo and Nicholas M. Anstey

    BMC Infectious Diseases 2017 17:312

    Published on: 27 April 2017

  8. Case report

    Severe type 1 upgrading leprosy reaction in a renal transplant recipient: a paradoxical manifestation associated with deficiency of antigen-specific regulatory T-cells?

    Due to its chronic subclinical course and large spectrum of manifestations, leprosy often represents a diagnostic challenge. Even with proper anti-mycobacteria treatment, leprosy follow up remains challenging:...

    Ana Paula Vieira, Maria Angela Bianconcini Trindade, Flávio Jota de Paula, Neusa Yurico Sakai-Valente, Alberto José da Silva Duarte, Francine Brambate Carvalhinho Lemos and Gil Benard

    BMC Infectious Diseases 2017 17:305

    Published on: 24 April 2017

  9. Research article

    Early detection of multidrug- and pre-extensively drug-resistant tuberculosis from smear-positive sputum by direct sequencing

    Emergence of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) is a major hurdle for TB control programs especially in developing countries like China. Resistance to fluoroquinolones is high am...

    Jun Chen, Peng Peng, Yixiang Du, Yi Ren, Lifeng Chen, Youyi Rao and Weihua Wang

    BMC Infectious Diseases 2017 17:300

    Published on: 24 April 2017

  10. Research article

    Digital CXR with computer aided diagnosis versus symptom screen to define presumptive tuberculosis among household contacts and impact on tuberculosis diagnosis

    Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However,...

    Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya and Helen Ayles

    BMC Infectious Diseases 2017 17:301

    Published on: 24 April 2017

  11. Research article

    Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis

    African pouched rats sniffing sputum samples provided by local clinics have significantly increased tuberculosis case findings in Tanzania and Mozambique. The objective of this study was to determine the repro...

    Haylee Ellis, Christiaan Mulder, Emilio Valverde, Alan Poling and Timothy Edwards

    BMC Infectious Diseases 2017 17:298

    Published on: 24 April 2017

  12. Research article

    Predictors of delayed culture conversion among Ugandan patients

    Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. T...

    Daniel Atwine, Patrick Orikiriza, Ivan Taremwa, Arnold Ayebare, Suzan Logoose, Juliet Mwanga-Amumpaire, Amina Jindani and Maryline Bonnet

    BMC Infectious Diseases 2017 17:299

    Published on: 24 April 2017

  13. Research article

    Determinants of delayed care seeking for TB suggestive symptoms in Seru district, Oromiya region, Ethiopia: a community based unmatched case-control study

    Early tuberculosis (TB) case finding and adequate chemotherapy are essential for interrupting disease transmission and preventing complications due to delayed care seeking. This study was undertaken in order t...

    Robel Yirgu, Firaol Lemessa, Selamawit Hirpa, Abraham Alemayehu and Eveline Klinkenberg

    BMC Infectious Diseases 2017 17:292

    Published on: 20 April 2017

  14. Research article

    Complications of miliary tuberculosis: low mortality and predictive biomarkers from a UK cohort

    Untreated, miliary tuberculosis (TB) has a mortality approaching 100%. As it is uncommon there is little specific data to guide its management. We report detailed data from a UK cohort of patients with miliary...

    Jonathan Underwood, Fiona Cresswell, Alex P Salam, Alex J Keeley, Charles Cleland, Laurence John and Robert N Davidson

    BMC Infectious Diseases 2017 17:295

    Published on: 20 April 2017

  15. Research article

    Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples

    Multi drug resistant tuberculosis (MDR-TB) poses formidable challenges to TB control due to its complex diagnostic and treatment challenges and often associated with a high rate of mortality. Accurate and rapi...

    Abyot Meaza, Abebaw Kebede, Zelalem Yaregal, Zekarias Dagne, Shewki Moga, Bazezew Yenew, Getu Diriba, Helina Molalign, Mengistu Tadesse, Desalegn Adisse, Muluwork Getahun and Kassu Desta

    BMC Infectious Diseases 2017 17:280

    Published on: 17 April 2017

  16. Research article

    TST positivity in household contacts of tuberculosis patients: a case-contact study in Malawi

    Screening household contacts of active tuberculosis (TB) patients is recommended for TB control. Due to resource constraints this rarely occurs in lower income countries. Demographic and clinical features of i...

    Jonas Hector, Suzanne T. Anderson, Gertrude Banda, Mercy Kamdolozi, Laura F. Jefferys, Doris Shani, Natalie J. Garton, Agnes Mwale, Annie Jobe, Geraint R. Davies and Derek J Sloan

    BMC Infectious Diseases 2017 17:259

    Published on: 11 April 2017

  17. Research article

    Assessments of serum copper and zinc concentration, and the Cu/Zn ratio determination in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) in Côte d’Ivoire

    In Côte d’Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. Zinc and copper are essential Trace element needed to strengthen the ...

    Gnogbo Alexis Bahi, Lydie Boyvin, Souleymane Méité, Gervais Melaine M’Boh, Kadjowely Yeo, Kouassi Raymond N’Guessan, Alain Dit Philippe Bidié and Allico Joseph Djaman

    BMC Infectious Diseases 2017 17:257

    Published on: 11 April 2017

  18. Research article

    Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens for latent tuberculosis infection: a systematic review with network meta-analyses

    We conducted a systematic review and network meta-analysis (NMA) to examine the efficacy and completion rates of treatments for latent tuberculosis infection (LTBI). While a previous review found newer, short-...

    Christopher Pease, Brian Hutton, Fatemeh Yazdi, Dianna Wolfe, Candyce Hamel, Pauline Quach, Becky Skidmore, David Moher and Gonzalo G. Alvarez

    BMC Infectious Diseases 2017 17:265

    Published on: 11 April 2017

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