Parasitological diseases

Section edited by Honorine Ward & Laith Yakob 

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of parasitological diseases in humans, as well as related studies on molecular and cellular biology, pathophysiology, and epidemiology.

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  1. Case report

    Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status

    Following its recent certification as malaria-free, imported infections now pose the greatest threat for maintaining this status in Sri Lanka. Imported infections may also introduce species that are uncommon o...

    Sharmini Gunawardena, Rachel F. Daniels, Thishan C. Yahathugoda, Mirani V. Weerasooriya, Katelyn Durfee, Sarah K. Volkman, Dyann F. Wirth and Nadira D. Karunaweera

    BMC Infectious Diseases 2017 17:307

    Published on: 24 April 2017

  2. Research article

    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya

    Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonize...

    Elly O. Munde, Winnie A. Okeyo, Evans Raballah, Samuel B. Anyona, Tom Were, John M. Ong’echa, Douglas J. Perkins and Collins Ouma

    BMC Infectious Diseases 2017 17:289

    Published on: 20 April 2017

  3. Research article

    Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya

    Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic suscepti...

    Elly O. Munde, Evans Raballah, Winnie A. Okeyo, John M. Ong’echa, Douglas J. Perkins and Collins Ouma

    BMC Infectious Diseases 2017 17:291

    Published on: 20 April 2017

  4. Technical advance

    1H-NMR analysis of feces: new possibilities in the helminthes infections research

    Analysis of the stool samples is an essential part of routine diagnostics of the helminthes infections. However, the standard methods such Kato and Kato-Katz utilize only a fraction of the information availabl...

    Sarantos Kostidis, Daria Kokova, Natalia Dementeva, Irina V. Saltykova, Hye Kyong Kim, Young Hae Choi and Oleg A. Mayboroda

    BMC Infectious Diseases 2017 17:275

    Published on: 17 April 2017

  5. Research article

    Modelling the therapeutic dose range of single low dose primaquine to reduce malaria transmission through age-based dosing

    Low-dose primaquine is a key candidate for use in malaria transmission reduction and elimination campaigns such as mass drug administration (MDA). Uncertainty about the therapeutic dose range (TDR) required fo...

    Daniel Joseph Hayes, Clifford George Banda, Alexandra Chipasula-Teleka and Dianne Janette Terlouw

    BMC Infectious Diseases 2017 17:254

    Published on: 8 April 2017

  6. Research article

    Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection

    While the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hook...

    Lívia Silva Araújo Passos, Pedro Henrique Gazzinelli-Guimarães, Tiago Antônio de Oliveira Mendes, Ana Clara Gazzinelli Guimarães, Denise da Silveira Lemos, Natasha Delaqua Ricci, Ricardo Gonçalves, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno

    BMC Infectious Diseases 2017 17:253

    Published on: 8 April 2017

  7. Research article

    Clinical diagnostic value of viable Schistosoma japonicum eggs detected in host tissues

    Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved...

    Kongzhen Gu, Yuesheng Li, Patrick Driguez, Qingren Zeng, Xinlin Yu, Hui Sun, Liting Cai, Yongkang He, Wenyang Wang and Donald P. McManus

    BMC Infectious Diseases 2017 17:244

    Published on: 4 April 2017

  8. Research article

    Development of a rapid loop-mediated isothermal amplification assay for diagnosis and assessment of cure of Leishmania infection

    Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test ...

    Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh and Poonam Salotra

    BMC Infectious Diseases 2017 17:223

    Published on: 23 March 2017

  9. Research article

    Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status

    Chagas disease is caused by the protozoan Trypanosoma cruzi and is characterized by heart failure and sudden death. Identifying which factors are involved in evolution and treatment response is actually challengi...

    Héctor Rodríguez-Angulo, Juan Marques, Ivan Mendoza, Marco Villegas, Alfredo Mijares, Núria Gironès and Manuel Fresno

    BMC Infectious Diseases 2017 17:221

    Published on: 21 March 2017

  10. Research article

    Lack of association between Toxoplasma gondii exposure and depression in pregnant women: a case-control study

    Very little is known about the link of T. gondii infection and depression. Through an age-, gender-, and month of pregnancy-matched case-control study, we determined the association of T. gondii infection and dep...

    Cosme Alvarado-Esquivel, Ana Liliana Martínez-Martínez, Luis Francisco Sánchez-Anguiano, Jesús Hernández-Tinoco, Juan Manuel Castillo-Orona, Carlos Salas-Martínez, Antonio Sifuentes-Álvarez, Ada Agustina Sandoval-Carrillo, José M. Salas-Pacheco, Oliver Liesenfeld and Elizabeth Irasema Antuna-Salcido

    BMC Infectious Diseases 2017 17:190

    Published on: 6 March 2017

  11. Research article

    Screening of TNFα, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study

    Clinical manifestations of cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) range from asymptomatic infection to self-limited, or chronic (non-healing) cutaneous lesions. Given the critical role of the...

    Angélica Mera-Ramírez, Andrés Castillo, Yenifer Orobio, María Adelaida Gómez and Carolina Gallego-Marin

    BMC Infectious Diseases 2017 17:177

    Published on: 28 February 2017

  12. Research article

    Hyponatremia and risk factors for death in human visceral leishmaniasis: new insights from a cross-sectional study in Brazil

    Visceral leishmaniasis (VL) is an important and potentially fatal neglected tropical disease. The aim of this study was to investigate hyponatremia and risk factors for death among VL patients.

    Elizabeth De Francesco Daher, Douglas de Sousa Soares, Sérgio Luiz Arruda Parente Filho, Gdayllon Cavalcante Meneses, Tainá Veras de Sandes Freitas, Tacyano Tavares Leite and Geraldo Bezerra da Silva Junior

    BMC Infectious Diseases 2017 17:168

    Published on: 23 February 2017

  13. Research article

    Field evaluation of a recombinase polymerase amplification assay for the diagnosis of Schistosoma japonicum infection in Hunan province of China

    Current diagnostic methods for Schistosoma japonicum infection are insensitive for low-density infections. Therefore, a new diagnostic assay based on recombinase polymerase amplification (RPA) technology was esta...

    Weiwei Xing, Xinling Yu, Jingtao Feng, Kui Sun, Wenliang Fu, Yuanyuan Wang, Minji Zou, Wenrong Xia, Zhihong Luo, Hongbin He, Yuesheng Li and Donggang Xu

    BMC Infectious Diseases 2017 17:164

    Published on: 21 February 2017

  14. Case report

    Report of three imported cases of neurocysticercosis in Guadeloupe

    Neurocysticercosis is endemic in most countries of Central and South America but has rarely been described in the French West Indies. We aimed to better understand the clinical and radiological presentation of...

    R. Blaizot, B. Melot, K. Schepers, M. Nicolas, S. Gaumond, P. Poullain, L. Belaye, A. Lannuzel and B. Hoen

    BMC Infectious Diseases 2017 17:106

    Published on: 31 January 2017

  15. Research article

    Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria

    Early rising asexual parasitaemia (ERAP), initially defined as ‘an increase in the parasite count over the baseline pre-treatment level during the first 24 h of treatment’ of falciparum malaria with artemisini...

    Akintunde Sowunmi, Kazeem Akano, Adejumoke I. Ayede, Elsie O. Adewoye, Godwin Ntadom, Bayo Fatunmbi, Grace O. Gbotosho, Onikepe A. Folarin and Christian T. Happi

    BMC Infectious Diseases 2017 17:110

    Published on: 31 January 2017

  16. Case report

    A severe case of visceral leishmaniasis and liposomal amphotericin B treatment failure in an immunosuppressed patient 15 years after exposure

    Visceral leishmaniasis (VL) is a protozoan disease, which is responsible for 200.000–400.000 yearly infections worldwide. If left untreated, the fatality rate can be as high as 100% within 2 years. 90% of case...

    Anna Eichenberger, Annina E. Buechi, Andreas Neumayr, Chistroph Hatz, Andri Rauch, Marc Huguenot, Eva Diamantis-Karamitopoulou and Cornelia Staehelin

    BMC Infectious Diseases 2017 17:81

    Published on: 17 January 2017

  17. Research article

    Protection via a ROM4 DNA vaccine and peptide against Toxoplasma gondii in BALB/c mice

    Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite with a broad host range including most warm-blooded animals, including humans. T. gondii surface antigen 1...

    Yali Han, Aihua Zhou, Gang Lu, Guanghui Zhao, Lin Wang, Jingjing Guo, Pengxia Song, Jian Zhou, Huaiyu Zhou, Hua Cong and Shenyi He

    BMC Infectious Diseases 2017 17:59

    Published on: 11 January 2017

  18. Debate

    Gut microbiota disturbance during helminth infection: can it affect cognition and behaviour of children?

    Bidirectional signalling between the brain and the gastrointestinal tract is regulated at neural, hormonal, and immunological levels. Recent studies have shown that helminth infections can alter the normal gut...

    Vanina Guernier, Bradley Brennan, Laith Yakob, Gabriel Milinovich, Archie C. A. Clements and Ricardo J. Soares Magalhaes

    BMC Infectious Diseases 2017 17:58

    Published on: 10 January 2017

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