HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Research article

    Role of routine abdominal ultrasonography in intensified tuberculosis case finding algorithms at HIV clinics in high TB burden settings

    High proportion of TB in people living with HIV (PLHIV) is undiagnosed. Due to this active TB case finding is recommended for HIV clinics in high TB burden countries. Presently sputum examination and chest rad...

    Sonam Spalgais, Upasna Agarwal, Rohit Sarin, Devesh Chauhan, Anita Yadav and Anand Jaiswal

    BMC Infectious Diseases 2017 17:351

    Published on: 18 May 2017

  2. Research article

    HIV infection, hypercoagulability and ischaemic stroke in adults at the University Teaching Hospital in Zambia: a case control study

    In Zambia, 14.2% of adults have HIV/AIDS. There has been a substantial and significant increase in patients hospitalized for ischaemic stroke with co-existing HIV infection. However, little is known about the ...

    Stanley Zimba, Patrice Mukomena Ntanda, Shabir Lakhi and Masharip Atadzhanov

    BMC Infectious Diseases 2017 17:354

    Published on: 18 May 2017

  3. Research article

    Tryptophan catabolism and immune activation in primary and chronic HIV infection

    Kynurenine/Tryptophan ratio (KTR) is increased in HIV infection, and linked to immune activation. We hypothesized that early cART initiation results in lower KTR compared to late initiation. Furthermore, we hy...

    Marco Gelpi, Hans J. Hartling, Per M. Ueland, Henrik Ullum, Marius Trøseid and Susanne D. Nielsen

    BMC Infectious Diseases 2017 17:349

    Published on: 16 May 2017

  4. Research article

    A bio-behavioral intervention to decrease intravaginal practices and bacterial vaginosis among HIV infected Zambian women, a randomized pilot study

    Intravaginal practices (IVP) (cleansing or introducing products inside the vagina for hygiene, health or to please sexual partners) are common among women with HIV. IVP increase the risk of developing bacteria...

    Maria L. Alcaide, Maureen Chisembele, Emeria Malupande, Violeta J. Rodriguez, Margaret A. Fischl, Kristopher Arheart and Deborah L. Jones

    BMC Infectious Diseases 2017 17:338

    Published on: 12 May 2017

  5. Research article

    Factors Associated with Virological Non-suppression among HIV-Positive Patients on Antiretroviral Therapy in Uganda, August 2014–July 2015

    Despite the growing number of people on antiretroviral therapy (ART), there is limited information about virological non-suppression and its determinants among HIV-positive (HIV+) individuals enrolled in HIV c...

    Lilian Bulage, Isaac Ssewanyana, Victoria Nankabirwa, Fred Nsubuga, Christine Kihembo, Gerald Pande, Alex R. Ario, Joseph KB Matovu, Rhoda K. Wanyenze and Charles Kiyaga

    BMC Infectious Diseases 2017 17:326

    Published on: 3 May 2017

  6. Research article

    Universal test, treat, and keep: improving ART retention is key in cost-effective HIV control in Uganda

    With ambitious new UNAIDS targets to end AIDS by 2030, and new WHO treatment guidelines, there is increased interest in the best way to scale-up ART coverage. We investigate the cost-effectiveness of various A...

    Nicky McCreesh, Ioannis Andrianakis, Rebecca N. Nsubuga, Mark Strong, Ian Vernon, Trevelyan J. McKinley, Jeremy E. Oakley, Michael Goldstein, Richard Hayes and Richard G. White

    BMC Infectious Diseases 2017 17:322

    Published on: 3 May 2017

  7. Research article

    Prevalence of hepatitis B and C infection in persons living with HIV enrolled in care in Rwanda

    Hepatitis B (HBV) and C (HCV) are important causes of morbidity and mortality in people living with human immunodeficiency virus (HIV). The burden of these co-infections in sub-Saharan Africa is still unclear....

    Justine Umutesi, Bryony Simmons, Jean D. Makuza, Donatha Dushimiyimana, Aimable Mbituyumuremyi, Jean Marie Uwimana, Nathan Ford, Edward J. Mills and Sabin Nsanzimana

    BMC Infectious Diseases 2017 17:315

    Published on: 2 May 2017

  8. Research article

    Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease

    Cardiovascular disease (CVD) is an important cause of mortality among HIV-infected patients, however little is known about the burden of CVD among this population in Asia. We sought to quantify prevalence of C...

    Fuping Guo, Evelyn Hsieh, Wei Lv, Yang Han, Jing Xie, Yanling Li, Xiaojing Song and Taisheng Li

    BMC Infectious Diseases 2017 17:287

    Published on: 20 April 2017

  9. Research article

    Trends in baseline CD4 cell counts and risk factors for late antiretroviral therapy initiation among HIV-positive patients in Shanghai, a retrospective cross-sectional study

    There are few studies focus on the factors underlying the late initiation of ART in China. We analyzed the trends in the median CD4 cell counts among different patient groups over time and the risk factors for...

    Jianjun Sun, Li Liu, Jiayin Shen, Panpan Chen and Hongzhou Lu

    BMC Infectious Diseases 2017 17:285

    Published on: 19 April 2017

  10. Research article

    Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil

    The present study aimed to describe the genetic diversity of HIV-1, as well as the resistance profile of the viruses identified in HIV-1 infected pregnant women under antiretroviral therapy in the state of Par...

    Luiz Fernando Almeida Machado, Iran Barros Costa, Maria Nazaré Folha, Anderson Levy Bessa da Luz, Antonio Carlos Rosário Vallinoto, Ricardo Ishak and Marluisa Oliveira Guimarães Ishak

    BMC Infectious Diseases 2017 17:270

    Published on: 12 April 2017

  11. Research article

    Disparities in HIV and syphilis prevalence and risk factors between older male clients with and without steady sex partners in southwestern rural China

    Heterosexual intercourse accounted for 93% of reported HIV cases in Guangxi, and Guangxi had 10% of China’s total number of reported HIV cases. Older men are particularly vulnerable to STIs, for example, 46% o...

    Li Chen, Jenny H. His, Xinghua Wu, Zhiyong Shen, Huaxiang Lu, Huanhuan Chen, Hui Huang, Heng Zhang, Yuhua Ruan, Yiming Shao and Zhenzhu Tang

    BMC Infectious Diseases 2017 17:269

    Published on: 12 April 2017

  12. Research article

    Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

    HIV is increasingly considered a chronic illness. More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity. Exercise is a self-management approa...

    Kelly K. O’Brien, Anne-Marie Tynan, Stephanie A. Nixon and Richard H. Glazier

    BMC Infectious Diseases 2017 17:268

    Published on: 12 April 2017

  13. Research article

    HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects

    The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a higher risk of abacavir-associated hypersensitivity reaction (ABC HSR). HLA-B*57:01 allele prevalence varies in different po...

    Catherine Butkus Small, David A. Margolis, Mark S. Shaefer and Lisa L. Ross

    BMC Infectious Diseases 2017 17:256

    Published on: 11 April 2017

  14. Research article

    Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-...

    Inger Hee Mathiesen, Mohammad Salem, Jan Gerstoft, Julie Christine Gaardbo, Niels Obel, Court Pedersen, Henrik Ullum, Susanne Dam Nielsen and Ann-Brit Eg Hansen

    BMC Infectious Diseases 2017 17:262

    Published on: 11 April 2017

  15. Research article

    Comparison of atazanavir/ritonavir and darunavir/ritonavir based antiretroviral therapy for antiretroviral naïve patients

    Atazanavir/ritonavir and darunavir/ritonavir are common protease inhibitor-based regimens for treating patients with HIV. Studies comparing these drugs in clinical practice are lacking.

    Tony Antoniou, Leah Szadkowski, Sharon Walmsley, Curtis Cooper, Ann N. Burchell, Ahmed M. Bayoumi, Julio S. G. Montaner, Mona Loutfy, Marina B. Klein, Nima Machouf, Christos Tsoukas, Alexander Wong, Robert S. Hogg and Janet Raboud

    BMC Infectious Diseases 2017 17:266

    Published on: 11 April 2017

  16. Research article

    Efficacy and safety of switching from nevirapine immediate-release twice daily to nevirapine extended-release once daily in virologically suppressed HIV-infected patients: a retrospective cohort study in Taiwan

    Whether the non-inferior efficacy and safety results of switching virologically suppressed HIV-1-infected patients from nevirapine immediate-release (NVP-IR) to NVP extended-release (NVP-XR) demonstrated in th...

    Chun-Yuan Lee, Hui-Min Chang, Calvin M Kunin, Susan Shin-Jung Lee, Yao-Shen Chen and Hung-Chin Tsai

    BMC Infectious Diseases 2017 17:261

    Published on: 11 April 2017

  17. Research article

    Alcohol use disorders among people living with HIV/AIDS in Southern Brazil: prevalence, risk factors and biological markers outcomes

    Alcohol abuse is an important public health problem, frequently unrecognized among people living with HIV/AIDS (PLWHA), and requires investigation and intervention. It is usually associated with lower adherenc...

    Cláudio Moss da Silva, Raúl Andrés Mendoza-Sassi, Luisa Dias da Mota, Maíba Mikhael Nader and Ana Maria Barral de Martinez

    BMC Infectious Diseases 2017 17:263

    Published on: 11 April 2017

  18. Research article

    Hepatitis C co-infection is associated with an increased risk of incident chronic kidney disease in HIV-infected patients initiating combination antiretroviral therapy

    Combination antiretroviral therapy (cART) has reduced mortality from AIDS-related illnesses and chronic comorbidities have become prevalent among HIV-infected patients. We examined the association between hepa...

    Carmine Rossi, Janet Raboud, Sharon Walmsley, Curtis Cooper, Tony Antoniou, Ann N. Burchell, Mark Hull, Jason Chia, Robert S. Hogg, Erica E.M. Moodie and Marina B. Klein

    BMC Infectious Diseases 2017 17:246

    Published on: 4 April 2017

  19. Research article

    HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation

    Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV infe...

    Malene Hove-Skovsgaard, Julie Christine Gaardbo, Lilian Kolte, Kamilla Winding, Ingebjørg Seljeflot, Asbjørn Svardal, Rolf Kristian Berge, Jan Gerstoft, Henrik Ullum, Marius Trøseid and Susanne Dam Nielsen

    BMC Infectious Diseases 2017 17:234

    Published on: 29 March 2017

  20. Research article

    The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study

    Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptid...

    Kristin Brekke, Maja Sommerfelt, Mats Ökvist, Anne Margarita Dyrhol-Riise and Dag Kvale

    BMC Infectious Diseases 2017 17:228

    Published on: 24 March 2017

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