HIV and co-infections

Section edited by Carlo Torti and Andrea De Luca

This section aims to publish studies looking at all aspects of the prevention, diagnosis and management of HIV and HIV-associated infections in humans, as well as related molecular genetics, pathophysiology, and epidemiology. This section also aims to publish studies on the adverse events of HAART and non HIV-related comorbidities in the HAART era.

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  1. Research article

    The virological durability of first-line ART among HIV-positive adult patients in resource limited settings without virological monitoring: a retrospective analysis of DART trial data

    Few low-income countries have virological monitoring widely available. We estimated the virological durability of first-line antiretroviral therapy (ART) after five years of follow-up among adult Ugandan and Z...

    David I. Dolling, Ruth L. Goodall, Michael Chirara, James Hakim, Peter Nkurunziza, Paula Munderi, David Eram, Dinah Tumukunde, Moira J. Spyer, Charles F. Gilks, Pontiano Kaleebu, David T. Dunn and Deenan Pillay

    BMC Infectious Diseases 2017 17:160

    Published on: 21 February 2017

  2. Research article

    UK national clinical audit: management of pregnancies in women with HIV

    The potential for HIV transmission between a pregnant woman and her unborn child was first recognized in 1982. Since then a complex package of measures to reduce risk has been developed. This project aims to r...

    S. Raffe, H. Curtis, P. Tookey, H. Peters, A. Freedman and Y. Gilleece

    BMC Infectious Diseases 2017 17:158

    Published on: 20 February 2017

  3. Research article

    Prevalence of Human Immunodeficiency Virus and associated factors among Visceral Leishmaniasis infected patients in Northwest Ethiopia: a facility based cross-sectional study

    Visceral Leishmaniasis coinfection with HIV/AIDS has emerged as a series of disease pattern. It most often results in unfavorable responses to treatment, frequent relapses, and deaths. Scarce data is available...

    Mekuriaw Alemayehu, Mamo Wubshet, Nebiyu Mesfin and Abebaw Gebayehu

    BMC Infectious Diseases 2017 17:152

    Published on: 17 February 2017

  4. Research article

    Brain and liver pathology, amyloid deposition, and interferon responses among older HIV-positive patients in the late HAART era

    HIV+ patients on highly active antiretroviral therapy (HAART) with suppressed viral loads have a low incidence of HIV-associated dementia, but increased prevalence of milder forms of HIV-associated neurocognit...

    Isaac H. Solomon, Umberto De Girolami, Sukrutha Chettimada, Vikas Misra, Elyse J. Singer and Dana Gabuzda

    BMC Infectious Diseases 2017 17:151

    Published on: 17 February 2017

  5. Research article

    Survival of people living with HIV who defaulted from tuberculosis treatment in a cohort, Recife, Brazil

    Tuberculosis is a serious public health problem worldwide. It is the leading cause of death amongst people living with HIV, and default from tuberculosis (TB) treatment in people living with HIV increases the ...

    R Cunha, M Maruza, UR Montarroyos, I Coimbra, D de B Miranda-Filho, M de F Albuquerque, HR Lacerda and RAA Ximenes

    BMC Infectious Diseases 2017 17:137

    Published on: 10 February 2017

  6. Research article

    Successful TB treatment outcome and its associated factors among TB/HIV co-infected patients attending Gondar University Referral Hospital, Northwest Ethiopia: an institution based cross-sectional study

    Tuberculosis/Human immunodeficiency virus (TB/HIV) co-infection is bidirectional and synergistic which mainly affects interventions that have been taken on the area. Tb patients co-infected with HIV have poore...

    Yenework Sinshaw, Shitaye Alemu, Abel Fekadu and Mucheye Gizachew

    BMC Infectious Diseases 2017 17:132

    Published on: 8 February 2017

  7. Research article

    Is it still worthwhile to perform quarterly cd4+ t lymphocyte cell counts on hiv-1 infected stable patients?

    In the last 20 years routine T CD4+ lymphocyte (CD4+) cell count has proved to be a key factor to determine the stage of HIV infection and start or discontinue of prophylaxis for opportunistic infections. Howe...

    Antonio Di Biagio, Marta Ameri, Davide Sirello, Giovanni Cenderello, Enrico Di Bella, Lucia Taramasso, Barbara Giannini, Mauro Giacomini, Claudio Viscoli, Giovanni Cassola and Marcello Montefiori

    BMC Infectious Diseases 2017 17:127

    Published on: 6 February 2017

  8. Research article

    Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults

    Although Mycobacterium tuberculosis (TB) infection may cause extrapulmonary disease in HIV-infected adults, HIV-associated hepatic TB has been poorly characterized. Our objective was to describe hepatic TB in HIV...

    Lilishia Gounder, Pravikrishnen Moodley, Paul K. Drain, Andrew J. Hickey and Mahomed-Yunus S. Moosa

    BMC Infectious Diseases 2017 17:115

    Published on: 1 February 2017

  9. Research article

    Dysglycemia associations with adipose tissue among HIV-infected patients after 2 years of antiretroviral therapy in Mwanza: a follow-up cross-sectional study

    Data on the burden of dysglycemia among HIV-infected patients on antiretroviral therapy (ART) in Africa are limited. We determined the prevalence of pre-diabetes and diabetes among HIV-infected patients who st...

    George PrayGod, John Changalucha, Saidi Kapiga, Robert Peck, Jim Todd and Suzanne Filteau

    BMC Infectious Diseases 2017 17:103

    Published on: 30 January 2017

  10. Research article

    Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study

    Hyponatremia is a frequent electrolyte disorder in HIV-infected patients with a prevalence of up to 56% in the pre-cART era. Several studies have demonstrated that patients with hyponatremia are at an increase...

    Philippe Braconnier, Marc Delforge, Maria Garjau, Karl Martin Wissing and Stéphane De Wit

    BMC Infectious Diseases 2017 17:98

    Published on: 26 January 2017

  11. Research article

    The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa

    HIV-1 subtype C demonstrates several biological properties distinct from other viral subtypes. One such variation is the duplication of PTAP motif in p6 Gag. PTAP motif is a key player in viral budding. Here, ...

    Shilpee Sharma, Shambhu G. Aralaguppe, Melissa-Rose Abrahams, Carolyn Williamson, Clive Gray, Pachamuthu Balakrishnan, Shanmugam Saravanan, Kailapuri G. Murugavel, Suniti Solomon and Udaykumar Ranga

    BMC Infectious Diseases 2017 17:95

    Published on: 24 January 2017

  12. Research article

    Depression, alcohol use, and intimate partner violence among outpatients in rural Uganda: vulnerabilities for HIV, STIs and high risk sexual behavior

    Intimate partner violence (IPV), alcohol use, and depression are key vulnerabilities for HIV in Uganda, and taken together may have a synergistic effect on risk. Our objective was to investigate the associatio...

    Susan M. Kiene, Haruna Lule, Katelyn M. Sileo, Kazi Priyanka Silmi and Rhoda K. Wanyenze

    BMC Infectious Diseases 2017 17:88

    Published on: 19 January 2017

  13. Research article

    Prevalence of HIV and syphilis co-infection and associated factors among non-commercial men who have sex with men attending a sexually transmitted disease clinic in Shenzhen, China

    Although HIV and syphilis co-infection has been frequently observed in men who have sex with men (MSM), only few studies have focused on it. Different subgroups of MSM might exhibit heterogeneous HIV and syphi...

    Wenjie Dai, Zhenzhou Luo, Ruiwei Xu, Guanglu Zhao, Dan Tu, Lin Yang, Feng Wang, Yumao Cai, Lina Lan, Fuchang Hong, Tubao Yang and Tiejian Feng

    BMC Infectious Diseases 2017 17:86

    Published on: 18 January 2017

  14. Case report

    Toxoplasmosis-associated IRIS involving the CNS: a case report with longitudinal analysis of T cell subsets

    HIV-infected patients may present an unforeseen clinical worsening after initiating antiretroviral therapy known as immune reconstitution inflammatory syndrome (IRIS). This syndrome is characterized by a heigh...

    Rita Rb-Silva, Claudia Nobrega, Eugénia Reiriz, Soraia Almeida, Rui Sarmento-Castro, Margarida Correia-Neves and Ana Horta

    BMC Infectious Diseases 2017 17:66

    Published on: 13 January 2017

  15. Research article

    A pilot study of brisk walking in sedentary combination antiretroviral treatment (cART)- treated patients: benefit on soluble and cell inflammatory markers

    Chronic HIV infection is associated with low-level inflammation and increased risk of chronic diseases and mortality. The objective was to assess the effects of moderate intensity exercise on metabolic and inf...

    Matteo Bonato, Laura Galli, Laura Passeri, Valeria Longo, Gaspare Pavei, Simona Bossolasco, Cecilia Bertocchi, Massimo Cernuschi, Giuseppe Balconi, Giampiero Merati, Adriano Lazzarin, Antonio La Torre and Paola Cinque

    BMC Infectious Diseases 2017 17:61

    Published on: 11 January 2017

  16. Research article

    Qualitative insights into implementation, processes, and outcomes of a randomized trial on peer support and HIV care engagement in Rakai, Uganda

    People living with human immunodeficiency virus (HIV) who have not yet initiated antiretroviral therapy (ART) can benefit from being engaged in care and utilizing preventive interventions. Community-based peer...

    April Monroe, Gertrude Nakigozi, William Ddaaki, Jeremiah Mulamba Bazaale, Ronald H. Gray, Maria J. Wawer, Steven J. Reynolds, Caitlin E. Kennedy and Larry W. Chang

    BMC Infectious Diseases 2017 17:54

    Published on: 10 January 2017

  17. Study protocol

    Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa

    There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a shi...

    Hans Strijdom, Patrick De Boever, Gerhard Walzl, M. Faadiel Essop, Tim S. Nawrot, Ingrid Webster, Corli Westcott, Nyiko Mashele, Frans Everson, Stephanus T. Malherbe, Kim Stanley, Harald H. Kessler, Evelyn Stelzl and Nandu Goswami

    BMC Infectious Diseases 2017 17:41

    Published on: 7 January 2017

  18. Research article

    Associations of statins and antiretroviral drugs with the onset of type 2 diabetes among HIV-1-infected patients

    Statin use is associated with a modest increase in the incidence of type 2 diabetes mellitus (DM) among the general population. However, HIV-infected patients have a higher risk of developing DM, and it is unc...

    Vincenzo Spagnuolo, Laura Galli, Andrea Poli, Stefania Salpietro, Nicola Gianotti, Piermarco Piatti, Francesca Cossarini, Concetta Vinci, Elisabetta Carini, Adriano Lazzarin and Antonella Castagna

    BMC Infectious Diseases 2017 17:43

    Published on: 7 January 2017

  19. Research article

    Monophylogenetic HIV-1C epidemic in Ethiopia is dominated by CCR5-tropic viruses–an analysis of a prospective country-wide cohort

    CCR5 coreceptor using HIV-1 subtype C (HIV-1C) has been reported to dominate the Ethiopian epidemic. However, almost all data have been obtained from two large cities in the central and north-west regions and ...

    Amare Worku Kalu, Nigus Fikrie Telele, Solomon Gebreselasie, Daniel Fekade, Samir Abdurahman, Gaetano Marrone and Anders Sönnerborg

    BMC Infectious Diseases 2017 17:37

    Published on: 6 January 2017

  20. Research article

    High prevalence and low cure rate of tuberculosis among patients with HIV in Xinjiang, China

    Tuberculosis and HIV co-epidemics are problems in many parts of the world. Xinjiang is a high tuberculosis and HIV prevalence area in China. We aimed to investigate the prevalence and cure rate of tuberculosis...

    Rena Maimaiti, Yuexin Zhang, Kejun Pan, Peierdun Mijiti, Maimaitiali Wubili, Maimaitijiang Musa and Rune Andersson

    BMC Infectious Diseases 2017 17:15

    Published on: 5 January 2017

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