SATURN project is a European multicentre study that aims to provide an in-depth knowledge of ARB acquisition through the analysis of antibiotic classes, duration of treatment and dosage in the nosocomial setting by a multidisciplinary approach. The SATURN project website http://www.saturn-project.eu provides the information and details concerning the different WPs and the entire project.
Several outcomes will be obtained at the end of the study (December 2014, expected): the rate of acquisition of target ARB by 1,000 antibiotic-days according to different classes of antibiotics, duration of therapy, and antibiotic combinations (monotherapy versus combinations); risk factors associated with new colonisation by target ARB; and risks for nosocomial infections due to target ARB after a cycle of antibiotic therapy adjusted by length of hospitalisation and ward colonisation pressure.
The WP4 study is currently recruiting patients in all clinical centers. The accomplishment of the study will be pursued thanks to the great strive of all clinicians, nurses and microbiology staff in every study step. An advertising campaign (posters, stickers and pictures) was performed in the selected wards in order to thrill and sensitise the recruited staff.
The results of the study should lead to the design of specific infection control measures for preventing spread of ARB in hospitalised non-ICU patients undergoing antibiotic therapy. A potential benefit for selective screening in high-risk patients during antibiotic therapy or shorter duration of antibiotics in such patients might be hypothesised. Readily available colonisation information could impact empiric therapy for nosocomial infections or, for example, the potential need of mupirocin prophylaxis for patients colonised by MRSA during hospitalisation. Assessment of the usefulness of the recommendations derived from the results of the SATURN study should be of valuable help for those in charge of infection control, for hospital administrators, and for those managing budgets of large healthcare organisations.
We do expect that SATURN project results will have a direct impact on clinical practice, improving the appropriateness of antibiotic prescribing policy, the prevention of antibiotic-resistant infections and the heightener of patients' quality care.