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Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings

  • Alexandra Calmy1, 19Email author,
  • Eric Balestre2, 3,
  • Fabrice Bonnet2, 3, 4,
  • Andrew Boulle5,
  • Eduardo Sprinz6,
  • Robin Wood7,
  • Eric Delaporte8,
  • Eugène Messou9,
  • James McIntyre10,
  • Kamal Marhoum El Filali11,
  • Mauro Schechter12,
  • N Kumarasamy13,
  • David Bangsberg14,
  • Patrick McPhail15,
  • Stefaan Van Der Borght16,
  • Carlos Zala17,
  • Matthias Egger18,
  • Rodolphe Thiébaut2, 3,
  • François Dabis2, 3 and
  • the ART-LINC of IeDEA Collaboration (Asia, South America, East, Southern and West Africa)
BMC Infectious Diseases201212:147

Received: 25 January 2012

Accepted: 26 April 2012

Published: 28 June 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
25 Jan 2012 Submitted Original manuscript
11 Mar 2012 Reviewed Reviewer Report - Christopher Hoffmann
14 Mar 2012 Reviewed Reviewer Report - Maria Dorrucci
4 Apr 2012 Author responded Author comments - Alexandra CALMY
Resubmission - Version 2
4 Apr 2012 Submitted Manuscript version 2
26 Apr 2012 Editorially accepted
28 Jun 2012 Article published 10.1186/1471-2334-12-147

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

HIV Unit, Geneva University Hospital
Centre Inserm U897- Epidemiologie-Biostatistique, Univ. Bordeaux, ISPED
Centre Inserm U897- Epidemiologie-Biostatistique, INSERM, ISPED
Service de Médecine Interne et Maladies Infectieuses, Centre Hospitalier Universitaire (CHU)
School of Public Health and Family Medicine, University of Cape Town
South Brazil HIV Cohort, Hospital de Clinicas de Porto Alegre
Gugulethu ART Programme
Institut de Recherche et de Développement (IRD)
Centre de Prise en Charge, de Recherche et de Formation sur le VIH/SIDA (CePReF)
Perinatal HIV Research Unit, Operational Research on ART (OPERA)
Service des Maladies Infectieuses, Hôpital Ibn Rochd
Rio HIV Cohort
YRG Centre for AIDS Research and Education
Immune Suppression Syndrome Clinic (ISS)
Helen Joseph Hospital Themba Lethu Clinic
Heineken International Health Affairs
Prospective Evaluation in the Use and Monitoring of Antiretrovirals in Argentina (PUMA)
Institute of Social and Preventive Medicine (ISPM), University of Bern
4 rue Gabrielle Perret Gentil, Geneva University Hospital