Tick-borne lymphadenopathy (TIBOLA) acquired in Southwestern Germany
© Rieg et al; licensee BioMed Central Ltd. 2011
Received: 1 February 2011
Accepted: 10 June 2011
Published: 10 June 2011
Tick-borne lymphadenopathy (TIBOLA) was first described in 1997 in a patient in France. The causative agent, Rickettsia slovaca, is transmitted by Dermacentor ticks.
In southwestern Germany we encountered a patient with a tick bite at the dorsal scalp that resulted in an eschar and nuchal lymphadenopathy. Additionally, fever, malaise as well as elevated inflammatory markers and transaminases occurred. The characteristic clinical picture along with positive antibody testing for rickettsiae of the tick-borne spotted fever group strongly suggest the diagnosis TIBOLA.
Human rickettsioses are emerging infections. Clinicians should be aware of TIBOLA as a newly described rickettsial disease. As in our case, TIBOLA may be encountered in regions/countries where R. slovaca and Dermacentor ticks are prevalent but autochthonous acquisition was not described before.
Rickettsiae are obligate intracellular gram negative bacteria transmitted in the natural environment by vectors such as ticks, fleas, lice, and mites. Of medical importance are Rickettsiae of the typhus group (R. prowazekii, R. typhi) and Rickettsiae of the tick-borne spotted fever group (e.g. R. rickettsii, R. conorii, R. africae), which now compromises more than 20 different species as several new species have been identified in recent years .
Tick-borne lymphadenopathy (TIBOLA) was first described in 1997 in a female patient in France and is defined as the association of a tick bite resulting in an inoculation eschar on the scalp and enlargened cervical lymphnodes in the absence of a rash . Although the causative agent of TIBOLA, Rickettsia slovaca, is prevalent in Dermacentor ticks in Germany, until 2009 no case of TIBOLA has been described. Here we report the first case of TIBOLA acquired in Germany.
Here we report the case of a female Caucasian patient presenting with the characteristic clinical features of TIBOLA. In our patient the tick was not available for genus and species identification, however, the season late winter/early spring and the localisation of the tick bite on the scalp strongly suggest a bite due to D. marginatus which is prevalent in the vicinity of Freiburg. Noteworthy, TIBOLA is one of the rare tick-borne diseases that is more common in the cold season. As reported in several case series, females are at higher risk of TIBOLA, the mean age is 30-35 years with a substantial proportion of cases occurring in children. Apart from TIBOLA, two other acronyms were proposed for this clinical entity: Dermacentor-borne necrosis erythema and lymphadenopathy (DEBONEL) or scalp eschar and neck lymphadenopathy after tick bite (SENLAT) .
R. slovaca has been described in Dermacentor ticks in many European countries including France, Greece, Hungary, Spain, Italy, Switzerland, Austria, Russia, Ukraine, Armenia, and others. In Germany, R. slovaca has been found in D. marginatus ticks in Baden-Wuerttemberg in the area of the Rhine valley  and recently in the Main valley in the vicinity of Aschaffenburg, Bavaria .
Within the last years, detection of R. slovaca from human cases has been increasingly reported from France, Hungary, Spain and Italy [4, 8–10]. It is remarkable that although R. slovaca was isolated in ticks in Germany already 30 years ago, no human case of TIBOLA in Germany has been described until recently. As a consequence of the case presented here and another case of 2009 from southern Rhineland-Palatinate , Germany must be added to the list of countries where autochthonous acquisition of TIBOLA has occurred. R. slovaca infections seem to be more widespread over Germany as has been found so far since our case was several hundred kilometers south of the case described in Rhineland-Palatinate. Including the recently described detection of Rickettsia aeschlimannii, up to now seven rickettsial species have been reported in Germany .
Apart from R. slovaca, the rickettsial genotypes RpA4, DnS14 and DnS28 belonging to a new spotted fever group species recently named R. raoultii have been implicated in the etiology of TIBOLA . Due to only minor antigenetic differences among all spotted fever group rickettsiae, serology is not able to discriminate within members of this group and unambiguous (sub)species-specific diagnosis can only be made by PCR from skin biopsies or swab specimen of the eschar . As R. raoultii is prevalent in D. reticulatis ticks in southern Germany and skin biopsy/PCR was not performed, we cannot rule out TIBOLA due to R. raoultii. However, our patient suffered from high fever and pronounced malaise. This strongly favours an infection due to R. slovaca since R. raoultii is considered to be less pathogenic and to cause a milder form of TIBOLA [12, 14].
Noteworthy, apart from fever and malaise our patient presented with moderately elevated transaminases indicating hepatic involvement in the course of infection. Further evaluation included abdominal/hepatic ultrasonography which was unremarkable. Antibody testing for Coxiella burnetii was negative. Improvement of ALT/AST during antibiotic treatment argues against drug induced hepatitis due to ampicillin/sulbactam or ciprofloxacin.
The differential diagnosis in patients with an eschar includes rickettsial infections, cutaneous anthrax, tularaemia, necrotic arachnidism (brown recluse spider bite), scrub typhus (Orientia tsutsugamushi), rat bite fever (Spirillum minus), staphylococcal or streptococcal ecthyma, and, as discussed recently, infection due to Bartonella henselae . However, in the context of a previous tick bite, infection due to Francisella tularensis, or possibly B. henselae, as well as staphylococcal or streptococcal superinfection occur as most likely diagnoses.
As for other rickettsioses the treatment of choice is considered to be a 7 to 10 day course of doxycycline (100 mg twice daily for adults), with ciprofloxacin or azithromycin/clarithromycin as possible alternative agents. Severe complications as seen in other rickettsiosis (e.g. epidemic typhus, Rocky Mountain Spotted Fever, Mediterranean Spotted Fever) have not been described in TIBOLA so far.
Our knowledge on geographic distribution, epidemiology and ecology of rickettsiae is currently evolving. The prevalence of rickettsial diseases in Germany and elsewhere is probably underestimated. TIBOLA should be noticed as an emerging infection, partly due to an increasing spread of Dermacentor marginatus ticks. Clinicians should be aware of TIBOLA as a tick-borne disease as well as of the local prevalence of rickettsial species and their potential vectors. In typical cases (as in the patient reported here) awareness of TIBOLA enables a rather reliable clinical diagnosis that typically results in incisive diagnostic approaches and simple, unexpensive treatment.
Written informed consent was obtained from the patient for publication of this case report.
Acknowledgements and Funding
We thank Prof. Heinz Mehlhorn, Duesseldorf University, for providing the photograph of Dermacentor spp. and Prof. Mathias Langer, Radiology Department, University Hospital Freiburg, for providing the computed tomography scans.
- Dobler G, Wolfel R: Typhus and other rickettsioses: emerging infections in Germany. Dtsch Arztebl Int. 2009, 106: 348-354.PubMedPubMed CentralGoogle Scholar
- Raoult D, Berbis P, Roux V, Xu W, Maurin M: A new tick-transmitted disease due to Rickettsia slovaca. Lancet. 1997, 350: 112-113.View ArticlePubMedGoogle Scholar
- Walker DH, Paddock CD, Dumler JS: Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections. Med Clin North Am. 2008, 92: 1345-61. 10.1016/j.mcna.2008.06.002.View ArticlePubMedGoogle Scholar
- Lakos A: Tick-borne lymphadenopathy--a new rickettsial disease?. Lancet. 1997, 350: 1006-10.1016/S0140-6736(05)64072-X.View ArticlePubMedGoogle Scholar
- Angelakis E, Pulcini C, Waton J, Imbert P, Socolovschi C, Edouard S, et al: Scalp eschar and neck lymphadenopathy caused by Bartonella henselae after Tick Bite. Clin Infect Dis. 2010, 50: 549-551. 10.1086/650172.View ArticlePubMedGoogle Scholar
- Rehacek J, Liebisch A, Urvolgyi J, Kovacova E: Rickettsiae of the spotted fever isolated from Dermacentor marginatus ticks in South Germany. Zentralbl Bakteriol Orig A. 1977, 239: 275-281.PubMedGoogle Scholar
- Pluta S, Tewald F, Hartelt K, Oehme R, Kimmig P, Mackenstedt U: Rickettsia slovaca in Dermacentor marginatus ticks, Germany. Emerg Infect Dis. 2009, 15: 2077-2078.View ArticlePubMedPubMed CentralGoogle Scholar
- Oteo JA, Ibarra V, Blanco JR, Martinez dAV, Marquez FJ, Portillo A, et al: Dermacentor-borne necrosis erythema and lymphadenopathy: clinical and epidemiological features of a new tick-borne disease. Clin Microbiol Infect. 2004, 10: 327-331. 10.1111/j.1198-743X.2004.00782.x.View ArticlePubMedGoogle Scholar
- Raoult D, Lakos A, Fenollar F, Beytout J, Brouqui P, Fournier PE: Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticks. Clin Infect Dis. 2002, 34: 1331-1336. 10.1086/340100.View ArticlePubMedGoogle Scholar
- Selmi M, Bertolotti L, Tomassone L, Mannelli A: Rickettsia slovaca in Dermacentor marginatus and tick-borne lymphadenopathy, Tuscany, Italy. Emerg Infect Dis. 2008, 14: 817-820. 10.3201/eid1405.070976.View ArticlePubMedPubMed CentralGoogle Scholar
- Rumer L, Graser E, Hillebrand T, Talaska T, Dautel H, Mediannikov O, et al: Rickettsia aeschlimannii in Hyalomma marginatum ticks, Germany. Emerg Infect Dis. 2011, 17: 325-326.View ArticlePubMedPubMed CentralGoogle Scholar
- Parola P, Rovery C, Rolain JM, Brouqui P, Davoust B, Raoult D: Rickettsia slovaca and R. raoultii in tick-borne Rickettsioses. Emerg Infect Dis. 2009, 15: 1105-1108. 10.3201/eid1507.081449.View ArticlePubMedPubMed CentralGoogle Scholar
- Bechah Y, Socolovschi C, Raoult D: Identification of rickettsial infections by using cutaneous swab specimens and PCR. Emerg Infect Dis. 2011, 17: 83-86.View ArticlePubMedPubMed CentralGoogle Scholar
- Ibarra V, Oteo JA, Portillo A, Santibanez S, Blanco JR, Metola L, et al: Rickettsia slovaca infection: DEBONEL/TIBOLA. Ann N Y Acad Sci. 2006, 1078: 206-214. 10.1196/annals.1374.040.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/11/167/prepub