Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study
© Silva et al; licensee BioMed Central Ltd. 2010
Received: 13 July 2009
Accepted: 7 March 2010
Published: 7 March 2010
To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity.
We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included. Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.
During the study period, 67 patients with TB required intensive care. Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died. Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.
In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.
Across the world tuberculosis (TB) remains an important public health problem, especially in developing countries. One third of the world's population is infected with Mycobacterium tuberculosis. Brazil is ranking 15th among the 22 high-burden countries that collectively account for 80% of TB cases globally. The incidence of TB was of 50 cases/100,000 population/yr in 2006, and recently reached approximately 100 cases/100,000 population in the city of Porto Alegre (southern Brazil) . Every year, almost 2 million people die of TB, most of them in low- and middle-income countries. The annual death rate from TB in Brazil was estimated at 4.0/100,000 population/yr in 2006 .
Despite the availability of curative therapy, a large proportion of patients with TB are being hospitalized. In-hospital mortality rates remain high, particularly among patients with TB requiring intensive care unit (ICU) admission. These cases represent 1-3% of all patients with TB . Acute respiratory failure (ARF) caused by TB necessitating mechanical ventilation (MV) has been associated with mortality rates between 25.9% and 81% [3–6]. Furthermore, such patients have a prognosis significantly worse than patients with nontuberculous pneumonia requiring MV .
Some studies reported a few factors that contribute to mortality among critically ill patients with TB. Disseminated disease, usually in the setting of human immunodeficiency virus (HIV) infection, has been recognized as an important predictor of death. Other factors that can influence mortality rates are extensive fibrocavitary disease and consolidations on chest radiographs. Acute respiratory distress syndrome (ARDS), sepsis and multiple organ failure (MOF) also carry a very high mortality [5–7].
The purpose of this study was to describe the characteristics of patients with TB requiring intensive care, and to identify the factors that predict in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity.
This study was conducted in Porto Alegre, Brazil, from November 2005 through November 2007. Adult patients with TB that were admitted to the ICU of the Clinics Hospital of Porto Alegre (HCPA) were identified retrospectively. The HCPA is a general, tertiary care, university-affiliated hospital with 750 beds (34 adult ICU beds) and is a reference center for HIV in southern Brazil. Porto Alegre is the city with the highest acquired immunodeficiency syndrome (AIDS) incidence in Brazil (68.7 cases/100.000 population) . In our hospital, in 2008 for example, we had approximately 29.000 hospitalizations per year, with 185 cases of pulmonary TB. In addition, the number of outpatient visits was 551.968, but we do not have data on TB treatment, because our hospital does not provide TB treatment for outpatients; in Brazil, patients are treated in public outpatient health care services. The medical records of patients were reviewed, and predictors of mortality were assessed. The protocol was submitted to the Ethics Committee at HCPA and an approval was obtained. A waiver of consent was approved and the investigators assigned a confidentiality term.
Pulmonary TB is diagnosed according to the following criteria established in the Brazilian Guidelines for Tuberculosis : 1) detection by a direct test (Ziehl-Neelsen [ZN] method) - two positive samples; or 2) detection by a direct test (ZN method) - one positive sample and a positive culture result for Mycobacterium tuberculosis (in Löwenstein-Jensen [LJ] medium); or 3) detection by a direct test (ZN method) - one positive sample and radiological findings compatible with TB; or 4) only a positive culture result for Mycobacterium tuberculosis (in LJ medium); or 5) presence of clinical, epidemiologic and radiographic findings compatible with TB. The diagnosis of extra-pulmonary TB was based on clinical and/or complementary tests according with the location.
The following data were collected in a standardized questionnaire: demographic data (sex, age, race, years of schooling), smoking status, alcoholism, injection drug use, clinical form of TB, symptoms at admission, methods of diagnostic, presence of comorbidities, prior TB treatment, drug regimen, interval from hospital admission until initiation of treatment, delayed treatment (failure to initiate treatment within the first 24 hours after admission to hospital), reasons for ICU admission, interval from hospital admission until ICU admission (early ICU [admitted directly or transferred to an ICU within 4 days of admission] and late ICU [admitted to an ICU after 4 days of hospitalization]), ARF, ventilator-associated pneumonia (VAP), Acute Physiologic and Chronic Health Evaluation (APACHE) II scores, presence of organ failures, ARDS, sepsis, septic shock, length of hospital and ICU stay, length of mechanical ventilation, laboratory investigations (white cell count, hemoglobin, coagulation profile, liver and renal function parameters, albumin, C-reactive protein, blood gas analysis), Glasgow coma score, urine output, use of vasoactive drugs, hospitalization outcome (death or discharge), and outcome after discharge (cure, dropout, death). Data after discharge were obtained from SINAN (National System of Information on Notifiable Diseases). SINAN is a database from the Brazilian government which stores information concerning all notifiable infectious and contagious diseases. The duration of follow-up period was one year.
A diagnosis of respiratory failure was made after the determination of arterial oxygen pressure (PaO2) level of less than 60 mmHg or arterial oxygen saturation (SaO2) < 90%, with or without elevation of arterial PCO2. ARDS was diagnosed based on the criteria defined in the American-European consensus conference . For the diagnosis of organ failure, the criteria by Knaus  were used. Multiple organ failure (MOF) was defined as the failure of more than one organ. Ventilator-associated pneumonia (VAP) was diagnosed based on the American Thoracic Society (ATS) criteria . Anemia was defined by hemoglobin levels < 13.5 g/dL for males and < 12.0 g/dL for females. Hypoalbuminemia was considered when serum albumin levels were less than 3.5 g/dL.
Data analysis was performed using SPSS 14.0 (Statistical Package for the Social Sciences, Chicago, Illinois). Data were presented as number of cases, mean ± standard deviation (SD), or median with interquartile range. Categorical comparisons were performed by chi-square test using Yates's correction if indicated or by Fisher's exact test. Continuous variables were compared using the t-test or Wilcoxon test. Variables with p < 0.20 in the univariate analysis were analyzed in the multivariate analyses. We have chosen this widespread adopted cutoff because using a more traditional level (P < 0.05) might fail to identify variables known to be important. In addition, confusion variables can affect estimates even when their level of significance does not reach 0.05. Kaplan-Meier survival curves were used to analyze the survival of patients. Those factors significantly associated with survival were further analyzed with the Cox proportional hazard model (method forward) adjusted by sex and age. Hazard ratio (HR) with 95% confidence interval (CI) was used to report the results. A two-sided p value < 0.05 was considered significant for all analyses.
Demographic and clinical characteristics of hospitalized patients with TB requiring intensive care
Nonsurvivors (n = 44)
Survivors (n = 23)
44.2 ± 13.8
41.2 ± 14.8
< 8 yr of schooling
Presence of any comorbidity
Renal chronic disease
Twenty four (35.8%) patients had pulmonary disease only, 21 (31.3%) had extrapulmonary disease only, and 22 (32.8%) had association of pulmonary and extrapulmonary disease. The most common symptoms were fever (44.8%), loss of weight (38.8%), cough (29.9%), and neurologic ones (22.4%). Reticular infiltrate (35.8%) was the most common radiographic finding, followed by consolidation (23.9%). Forty six patients collected a sputum sample, of whom 25 (54.3%) were sputum-smear positive. Mycobacterial cultures were positive in 35 (52.2%) patients (13 bronchoalveolar lavage, 8 pleural effusion, 3 spontaneous sputum, 3 bone marrow, 2 cerebrospinal fluid, 2 blood, 1 induced sputum, 1 fine needle aspiration of lymphonode, 1 ascitic fluid, 1 urine). In 9 (13.4%), TB diagnosis was based on clinical, epidemiologic and radiographic findings. The median interval from hospital admission until initiation of treatment was 3 days (range: 1 - 8).
The primary cause for ICU admission was ARF in 42 (62.7%) patients. Other reasons were cardiopulmonary arrest (10.4%), septic shock (7.5%), sepsis (6.0%), and altered sensorium (6.0%). The mean APACHE II score was 22.8 ± 6.8. Among ICU admissions, 18.9% and 81.1% were classified as early and late, respectively. At ICU admission, most of the patients had anemia (92.5%), with more than a half (52.2%) of these having hemoglobin levels < 9 g/dL. The white blood cell (WBC) count was less than 4000 mm-3 in 14 patients (20.9%) and more than 12000 mm-3 in 13 patients (19.4%). Hypoalbuminemia was present in 45 (67.2%) patients. Mean serum albumin level was 2.2 ± 0.8 g/dL.
Although only 6.0% and 7.5% of patients had sepsis and septic shock, respectively, most of the patients developed sepsis (95.5%) and septic shock (83.6%) during ICU stay. Only 9 (13.4%) patients developed ARDS. During the course of ICU stay, 20 (29.9%) patients were diagnosed with VAP, and over 80% of the patients had MOF. Almost all patients (95.5%) developed acute renal failure. Out of these patients, 29.9% required dialysis. The median duration of hospitalization was 25 days (range: 12.8 - 50), and the median ICU stay was 10 days (range: 3 - 16.8).
Characteristics of disease presentation of hospitalized patients with TB requiring intensive care
Nonsurvivors (n = 44)
Survivors (n = 23)
APACHE II score
22.4 ± 6.9
23.4 ± 6.8
Early ICU admission
Presence of at least one symptom
Isolated Pulmonary TB
Isolated Extrapulmonary TB
Pulmonary + Extrapulmonary TB
Milliary radiological pattern
WBC > 12000 mm-3
Hepatotoxicity during hospitalization
Duration of mechanical ventilation, d
Acute renal failure
Multiple organ failure
In this study, we aimed to evaluate, on a retrospective basis, the risk factors associated with mortality among patients with TB requiring intensive care. Overall, we found a high in-hospital mortality rate (65.7%) in patients with TB admitted to the ICU. Using multivariate analysis, we identified early ICU admission as the most important factor independently associated with patient mortality. In addition, VAP was as a protective factor for mortality.
Our results are consistent with previous epidemiological data. Other studies have shown mortality rates up to approximately 80% in TB patients with ARF requiring MV [3–6, 12]. In accordance with our findings, another study demonstrated an ICU mortality rate of 61% and an in-hospital mortality rate of 65.9% . Early ICU admission was independently associated with higher mortality in multivariate analysis. This finding is consistent with a previous study , and may be due to the more severe disease in these patients. Actually, this appears to be a plausible explanation as they have a higher incidence of acute renal failure compared to patients with a late ICU admission. Delayed treatment was also more frequent in this group, which confirms earlier observations [13, 14]. Another factor that contributes to the failure to initiate treatment within 24 hours after admission is the less classic presentation. Indeed, atypical features as sputum-smear negativity have been suggested to be associated with delays in both diagnosis and treatment and with mortality [13, 15, 16]. Our study showed that sputum smear-positivity and a miliary radiographic pattern were associated with a reduced risk of death. Surprisingly, we found in univariate and multivariate analysis that VAP was a further protective factor for mortality, in contrast with prior reports [4, 17]. Although not statistically significant, the mean duration of mechanical ventilation was longer in survivors compared with nonsurvivors, which could explain the higher incidence of VAP in the formers.
Our study has some methodological limitations. First, the information was obtained retrospectively from chart review and probably was not as complete and accurate as when data collection is done prospectively. Certain important factors that have been suggested as risk factors for mortality could not be included. Second, it must be considered that this is a single center study with small sample size. Despite these limitations, our results provide important implications for similar demographic areas and clinical settings.
In the present study, we observed a high incidence of acute renal failure. In univariate analysis, we found that acute renal failure was associated with death. Acute renal failure is a common condition that affects many ICU patients and is a well-recognized risk factor for mortality [18, 19]. However, the results reported across studies in TB patients with acute renal failure are inconsistent. Although acute renal failure was identified as an independent predictor of death in some studies [4, 6, 20], others [3, 12] did not find a significant impact of such complication on the mortality of critically ill TB patients.
Previous studies have shown a critical course in patients with miliary TB and in HIV-infected patients with TB [6, 21]. However, we did not find an association between a diagnosis of HIV and mortality in ICU patients. In fact, mortality in patients with TB-HIV coinfection seems to be related to the patient's overall degree of immunosuppression . In spite of the free access to HAART in Brazil and the high level of immunosuppression of our study population, only 13% of patients were receiving HAART at the time of hospitalization, which is probably related to poor or no adherence to treatment. Even so, CD4/mm3 count was not a predictor of death in these patients. Furthermore, serum albumin levels, reported by others as good predictors of CD4/mm3 lymphocyte counts in patients with TB , were not associated with mortality in our study. The lack of association between mortality and the HIV epidemic could be explained by the fact that our non-HIV population had a high proportion of comorbidities and were also too ill with high mortality rate.
We found that patients who used rifampicin-based regimens had a higher mortality rate, even though not confirmed in multivariate analysis. One hypothesis to explain such observation is the possibility of multidrug-resistant tuberculosis (MDR-TB). However, culture and sensitivity test to antituberculosis drugs were not routinely performed, so we could not estimate the prevalence of MDR-TB in our sample. On the other hand, uncertain enteric absorption in critically ill patients  and subtherapeutic serum levels of rifampicin, especially in HIV-positive population [24, 25], have been reported [26–28]. Drug interactions among antituberculosis drugs and HAART are also important factors to be considered. In addition, low serum albumin levels could impair drug absorption and was associated with low rifampicin and ethambutol concentrations . Whereas the great majority of our study sample is composed by HIV-positive patients and hypoalbuminemia was a prevalent finding, it is possible that some patients had low serum rifampicin levels that went undetected.
To our knowledge this is the first study in Brazil that described TB cases and their outcomes in patients requiring intensive care. While effective treatment is available on an outpatient basis, TB hospitalization and mortality rates are substantially high in our center. Patients with an early ICU admission have the highest risk of death. Some factors were significant only in univariate analysis, such as acute renal failure, miliary radiological pattern, smear-positive sputum and rifampicin-based regimens. The small sample size may have lacked sufficient statistical power to reveal an association with some of the factors. These results, if confirmed in a larger prospective study, could contribute to a better understanding of characteristics associated with mortality.
In conclusion, in this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission. Nevertheless, additional studies are necessary to confirm this data, taking into account other possible risk factors for mortality like MDR-TB and low serum levels of antituberculosis drugs, potentially improving the care of critically ill TB patients.
Funding Source: FIPE - Hospital de Clínicas de Porto Alegre.
- Prefeitura Municipal de Porto Alegre. Boletim Epidemiológico. Porto Alegre, Brasil, 2008. [http://lproweb.procempa.com.br/pmpa/prefpoa/sms/usu_doc/boletim_n_35.pdf]
- World Health Organization. Global Tuberculosis Control. Report 2008. [http://www.who.int]
- Frame RN, Johnson MC, Eichenhorn MS, Bower GC, Popovich J: Active tuberculosis in the medical intensive care unit: a 15-year retrospective analysis. Crit Care Med. 1987, 15: 1012-1014. 10.1097/00003246-198711000-00005.View ArticlePubMedGoogle Scholar
- Erbes R, Oettel K, Raffenberg M, Mauch H, Schimidt-Ioanas M, Lode H: Characteristics and outcome of patients with active pulmonary tuberculosis requiring intensive care. Eur Respir J. 2006, 27: 1223-1228. 10.1183/09031936.06.00088105.View ArticlePubMedGoogle Scholar
- Lee PL, Jerng JS, Chang YL, Chen CF, Hsueh PR, Yu CJ, Yang PC, Luh KT: Patient mortality of active pulmonary tuberculosis requiring mechanical ventilation. Eur Respir. 2003, 22: 141-147. 10.1183/09031936.03.00038703.View ArticleGoogle Scholar
- Penner C, Roberts D, Kunimoto D, Manfreda J, Long R: Tuberculosis as a primary cause of respiratory failure requiring mechanical ventilation. Am J Respir Crit Care Med. 1995, 151 (3 Pt 1): 867-872.View ArticlePubMedGoogle Scholar
- Ryu YJ, Koh WJ, Kang EH, Suh GY, Chung MP, Kim H, Kwon OJ: Prognostic factors in pulmonary tuberculosis requiring mechanical ventilation for acute respiratory failure. Respirology. 2007, 12: 406-411. 10.1111/j.1440-1843.2006.01007.x.View ArticlePubMedGoogle Scholar
- Sociedade Brasileira de Pneumologia e Tisiologia: II Diretrizes Brasileiras para Tuberculose. J Bras Pneumol. 2004, 30 (Supl 1): S1-S86.Google Scholar
- Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R: The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994, 149: 818-824.View ArticlePubMedGoogle Scholar
- Knaus WA, Draper EA, Wagner DP, Zimmerman JE: Prognosis in acute organ-system failure. Ann Surg. 1985, 202: 685-693. 10.1097/00000658-198512000-00004.View ArticlePubMedPubMed CentralGoogle Scholar
- American Thoracic Society: Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005, 171: 388-416. 10.1164/rccm.200405-644ST.View ArticleGoogle Scholar
- Zahar JR, Azoulay E, Klement E, De Lassance A, Lucet JC, Regnier B, Schlemmer B, Bedos JP: Delayed treatment contributes to mortality in ICU patients with severe active pulmonary tuberculosis and acute respiratory failure. Intensive Care Med. 2001, 27: 513-520. 10.1007/s001340000849.View ArticlePubMedGoogle Scholar
- Greenaway C, Menzies D, Fanning A, Grewal R, Yuan L, FitzGerald JM: Delay in diagnosis among hospitalized patients with active tuberculosis - Predictors and outcomes. Am J Respir Crit Care Med. 2002, 165: 927-933.View ArticlePubMedGoogle Scholar
- Pablos-Mendez A, Sterling TR, Frieden TR: The relationship between delayed or incomplete treatment and all-cause mortality in patients with tuberculosis. JAMA. 1996, 276: 1223-1228. 10.1001/jama.276.15.1223.View ArticlePubMedGoogle Scholar
- Dewan PK, Arguin PM, Kiryanova H, Kondroshova NV, Khorosheva TM, Laserson K: Risk factors for death during tuberculosis treatment in Orel, Russia. Int J Tuberc Lung Dis. 2004, 8: 598-602.PubMedGoogle Scholar
- Balabanova Y, Drobniewski F, Fedorin I, Zakharova S, Nicolayevskyy V, Atun R: The directly observed therapy short-course (DOTS) strategy in Samara Oblast, Russia Federation. Respir Res. 2006, 7: 44-54. 10.1186/1465-9921-7-44.View ArticlePubMedPubMed CentralGoogle Scholar
- Dahmash NS, Arora SC, Fayed DF, Chowdhury MN: Infections in critically ill patients: experience in MICU at a major teaching hospital. Infection. 1994, 22: 264-270. 10.1007/BF01739913.View ArticlePubMedGoogle Scholar
- Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW: Acute kidney injury, mortality, length of stay and costs in hospitalized patients. J Am Soc Nephrol. 2005, 16: 3365-3370. 10.1681/ASN.2004090740.View ArticlePubMedGoogle Scholar
- Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C: Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA. 2005, 294: 813-818. 10.1001/jama.294.7.813.View ArticlePubMedGoogle Scholar
- Piqueras AR, Marruecos L, Artigas A, Rodriguez C: Miliary tuberculosis and adult respiratory distress syndrome. Intensive Care Med. 1987, 13: 175-182. 10.1007/BF00254701.View ArticlePubMedGoogle Scholar
- Stoneburner R, Laroche E, Prevots R, Singh T, Blum S, Terry P, Reatrice S, Adler J: Survival in a cohort of human immunodeficiency virus-infected tuberculosis patients in New York City. Arch Intern Med. 1992, 152: 2033-2037. 10.1001/archinte.152.10.2033.View ArticlePubMedGoogle Scholar
- Jones BE, Oo MM, Taikwel EK, Qian D, Kumar A, Maslow ER, Barnes PF: CD4 cell counts in human immunodeficiency virus-negative patients with tuberculosis. Clin Infect Dis. 1997, 24: 988-991.View ArticlePubMedGoogle Scholar
- Thompson J: The intestinal response to critical illness. Am J Gastroenterol. 1995, 90: 190-200.PubMedGoogle Scholar
- Berning SE, Huitt GA, Iseman MD, Peloquin CA: Malabsorption of antituberculosis medications by a patient with AIDS [letter]. N Engl J Med. 1992, 327: 1817-1818.View ArticlePubMedGoogle Scholar
- Patel KB, Belmonte R, Crowe HM: Drug malabsorption and resistant tuberculosis in HIV-infected patients [letter]. N Engl J Med. 1995, 332: 336-337. 10.1056/NEJM199502023320518.View ArticlePubMedGoogle Scholar
- Kimerling ME, Phillips P, Patterson P, Hall M, Robinson A, Dunlap NE: Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients. Chest. 1998, 113: 1178-1183. 10.1378/chest.113.5.1178.View ArticlePubMedGoogle Scholar
- Metha JB, Shantaveerapa H, Byrd RP, Morton SE, Fountain F, Roy TM: Utility of rifampin blood levels in the treatment and follow-up of active pulmonary tuberculosis in patients who were slow to respond to routine directly observed therapy. Chest. 2001, 120: 1520-1524. 10.1378/chest.120.5.1520.View ArticleGoogle Scholar
- Weiner M, Benator D, Burman W, Peloquin CA, Khan A, Vernon A, Jones B, Silva-Trigo C, Zhao Z, Hodge T: Association between acquired rifamycin resistance and the pharmacokinetics of rifabutin and isoniazid among patients with HIV and tuberculosis. Clin Infect Dis. 2005, 40: 1481-1491. 10.1086/429321.View ArticlePubMedGoogle Scholar
- Tappero JW, Bradford WZ, Agerton TB, Hopewell P, Reingold AL, Lockman S, Oyewo A, Talbot EA, Kenyon TA, Moeti TL, Moffat HL, Peloquin CA: Serum concentrations of antimycobacterial drugs in patients with pulmonary tuberculosis in Botswana. Clin Infect Dis. 2005, 41: 461-469. 10.1086/431984.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/10/54/prepub
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